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Relationship Between Obesity, Alzheimer’s Disease, and Parkinson’s Disease: an Astrocentric View

dc.contributor.authorMartin-Jiménez C.A.
dc.contributor.authorGaitán-Vaca D.M.
dc.contributor.authorEcheverria V.
dc.contributor.authorGonzález J.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:22:22Z
dc.date.available2020-09-02T22:22:22Z
dc.date.issued2017
dc.identifier10.1007/s12035-016-0193-8
dc.identifier.citation54, 9, 7096-7115
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5210
dc.descriptionObesity is considered one of the greatest risk to human health and is associated with several factors including genetic components, diet, and physical inactivity. Recently, the relationship between obesity and numerous progressive and aging-related neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) have been observed. Thus, the involvement of the most abundant and heterogeneous group of glial cells in neurodegenerative diseases, the astrocytes, is caused by a combination of the failure on their normal homeostatic functions and the increase of toxic metabolites upon pathological event. Upon brain damage, molecular signals induce astrocyte activation and migration to the site of injury, entering in a highly active state, with the aim to contribute to ameliorating or worsening the pathology. In this regard, the aim of this review is to elucidate the relationship between obesity, Alzheimer’s disease, and Parkinson’s disease and highlight the role of astrocytes in these pathologies. © 2016, Springer Science+Business Media New York.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectAlzheimer’s disease
dc.subjectAstrocytes
dc.subjectNeuroinflammation
dc.subjectObesity
dc.subjectParkinson’s disease
dc.subjectadvanced glycation end product
dc.subjectalpha synuclein
dc.subjectdopamine receptor
dc.subjectadipose tissue
dc.subjectAlzheimer disease
dc.subjectamyloid neuropathy
dc.subjectantiinflammatory activity
dc.subjectastrocyte
dc.subjectastrocytosis
dc.subjectcell function
dc.subjectcognition
dc.subjectdegenerative disease
dc.subjectdisease association
dc.subjectdisease course
dc.subjectdisease predisposition
dc.subjectfood intake
dc.subjecthormonal regulation
dc.subjecthuman
dc.subjecthyperglycemia
dc.subjectinsulin resistance
dc.subjectlife expectancy
dc.subjectlipid diet
dc.subjectmemory
dc.subjectnerve cell necrosis
dc.subjectnervous system inflammation
dc.subjectneurofibrillary tangle
dc.subjectnonhuman
dc.subjectobesity
dc.subjectParkinson disease
dc.subjectprevalence
dc.subjectReview
dc.subjectsenile plaque
dc.subjectsubstantia nigra
dc.subjectAlzheimer disease
dc.subjectanimal
dc.subjectastrocyte
dc.subjectbiological model
dc.subjectinflammation
dc.subjectobesity
dc.subjectParkinson disease
dc.subjectpathology
dc.subjectAlzheimer Disease
dc.subjectAnimals
dc.subjectAstrocytes
dc.subjectHumans
dc.subjectInflammation
dc.subjectModels, Biological
dc.subjectObesity
dc.subjectParkinson Disease
dc.titleRelationship Between Obesity, Alzheimer’s Disease, and Parkinson’s Disease: an Astrocentric View
dc.typeReview


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