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The potential role of bioengineering and three-dimensional printing in curing global corneal blindness

dc.contributor.authorLudwig P.E.
dc.contributor.authorHuff T.J.
dc.contributor.authorZuniga J.M.
dc.date.accessioned2020-09-02T22:21:50Z
dc.date.available2020-09-02T22:21:50Z
dc.date.issued2018
dc.identifier10.1177/2041731418769863
dc.identifier.citation9, , -
dc.identifier.issn20417314
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5118
dc.descriptionAn insufficiency of accessible allograft tissue for corneal transplantation leaves many impaired by untreated corneal disease. There is promise in the field of regenerative medicine for the development of autologous corneal tissue grafts or collagen-based scaffolds. Another approach is to create a suitable corneal implant that meets the refractive needs of the cornea and is integrated into the surrounding tissue but does not attempt to perfectly mimic the native cornea on a cellular level. Materials that have been investigated for use in the latter concept include natural polymers such as gelatin, semisynthetic polymers like gelatin methacrylate, and synthetic polymers. There are advantages and disadvantages inherent in natural and synthetic polymers: natural polymers are generally more biodegradable and biocompatible, while synthetic polymers typically provide greater control over the characteristics or property adjustment of the materials. Additive manufacturing could aid in the precision production of keratoprostheses and the personalization of implants. © The Author(s) 2018.
dc.language.isoen
dc.publisherSAGE Publications Ltd
dc.subjectadditive manufacturing
dc.subjectCornea
dc.subjecthydrogel
dc.subjectkeratoprosthesis
dc.subjectpolymer
dc.subjectcollagen type 1
dc.subjectcytokeratin 3
dc.subjectgelatin
dc.subjectmacrogol
dc.subjectmethacrylic acid
dc.subjectn,n dimethylacrylamide
dc.subjectpolitef
dc.subjectpoly(methyl methacrylate)
dc.subjectpolyglactin
dc.subjectpolymacon
dc.subjectpolyvinyl alcohol
dc.subjectbiocompatibility
dc.subjectbiodegradability
dc.subjectbioengineering
dc.subjectbiosynthesis
dc.subjectblindness
dc.subjectcell adhesion
dc.subjectcell structure
dc.subjectcell viability
dc.subjectcornea disease
dc.subjectcross linking
dc.subjectflow kinetics
dc.subjectFourier transform infrared spectroscopy
dc.subjecthuman
dc.subjecthydrogel
dc.subjectinflammation
dc.subjectkeratoplasty
dc.subjectpolymerization
dc.subjectpriority journal
dc.subjectReview
dc.subjectscanning electron microscopy
dc.subjectthree dimensional printing
dc.titleThe potential role of bioengineering and three-dimensional printing in curing global corneal blindness
dc.typeReview


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