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Treatment of epidermolysis bullosa with allogeneic human cultured queratinocytes [Bioingeniería de tejidos: Cultivo de queratinocitos humanos en el tratamiento de la epidermólisis bullosa]

dc.contributor.authorLorenzini V. N.
dc.contributor.authorManterola D. C.
dc.contributor.authorMoraga C. J.
dc.date.accessioned2020-09-02T22:21:48Z
dc.date.available2020-09-02T22:21:48Z
dc.date.issued2014
dc.identifier10.4067/S0718-40262014000400011
dc.identifier.citation66, 4, 359-363
dc.identifier.issn03793893
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5110
dc.descriptionBackground: Epidermolysis bullosa (EB) or "crystal skin" is a group of inherited disorders that affect the protein that forms the anchor between dermis and epidermis, producing blister injuries. Case report: We report a four years old boy with junctional EB and lesions in 80% of the body lasting 48 months. His right lower limb was treated with allogeneic human cultured queratinocytes during five weeks. After the treatment period, a re-epithelization of 90% of the intervened limb was observed. Its diameter increased from 23 to 27 cm, the wound assessment scale score decreased from 30 to 13 and the visual analogue pain assessment score decreased from eight to two. Therefore allogeneic human cultured queratinocytes are a novel therapeutic alternative for EB.
dc.language.isoen
dc.language.isoes
dc.publisherSociedad de Cirujanos de Chile
dc.subjectCell culture techniques [MeSH]
dc.subjectEpidermolysis bullosa
dc.subjectJunctional [MeSH]
dc.subjectKeratinocytes [MeSH]
dc.subjectTissue engineering [MeSH]
dc.subjectWound and injuries [MeSH]
dc.titleTreatment of epidermolysis bullosa with allogeneic human cultured queratinocytes [Bioingeniería de tejidos: Cultivo de queratinocitos humanos en el tratamiento de la epidermólisis bullosa]
dc.typeArticle


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