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Metabolic changes following perinatal Asphyxia: Role of astrocytes and their interaction with neurons

dc.contributor.authorLogica T.
dc.contributor.authorRiviere S.
dc.contributor.authorHolubiec M.I.
dc.contributor.authorCastilla R.
dc.contributor.authorBarreto G.E.
dc.contributor.authorCapani F.
dc.date.accessioned2020-09-02T22:21:46Z
dc.date.available2020-09-02T22:21:46Z
dc.date.issued2016
dc.identifier10.3389/fnagi.2016.00116
dc.identifier.citation8, JUN, -
dc.identifier.issn16634365
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5092
dc.descriptionPerinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness. The interaction between neurons, astrocytes and endothelial cells plays a central role coupling energy supply with changes in neuronal activity. Traditionally, experimental research focused on neurons, whereas astrocytes have been more related to the damage mechanisms of PA. Astrocytes carry out a number of functions that are critical to normal nervous system function, including uptake of neurotransmitters, regulation of pH and ion concentrations, and metabolic support for neurons. In this work, we aim to review metabolic neuron-astrocyte interactions with the purpose of encourage further research in this area in the context of PA, which is highly complex and its mechanisms and pathways have not been fully elucidated to this day. © 2016 Logica, Riviere, Holubiec, Castilla, Barreto and Capani.
dc.language.isoen
dc.publisherFrontiers Research Foundation
dc.subjectAstrocyte
dc.subjectBrain
dc.subjectInteraction
dc.subjectMetabolism
dc.subjectNeuron
dc.subjectPerinatal asphyxia
dc.subjectglucose
dc.subjectglucose transporter 1
dc.subjectglucose transporter 3
dc.subjectglutamic acid
dc.subjectglutamine
dc.subjectglutathione
dc.subjectglycogen
dc.subjection
dc.subjectketone body
dc.subjectlactic acid
dc.subjectpotassium ion
dc.subjectsodium ion
dc.subjectastrocyte
dc.subjectblood brain barrier
dc.subjectbrain blood flow
dc.subjectbrain blood vessel
dc.subjectbrain development
dc.subjectcell interaction
dc.subjectcell metabolism
dc.subjectcell migration
dc.subjectenergy metabolism
dc.subjectenergy transfer
dc.subjectglia cell
dc.subjecthuman
dc.subjectimmaturity
dc.subjection transport
dc.subjectnerve cell
dc.subjectnerve cell differentiation
dc.subjectneurotransmission
dc.subjectnonhuman
dc.subjectoxidation reduction potential
dc.subjectpathogenesis
dc.subjectperinatal asphyxia
dc.subjectprimary energy failure
dc.subjectReview
dc.subjectsecondary energy failure
dc.subjectsynapse
dc.titleMetabolic changes following perinatal Asphyxia: Role of astrocytes and their interaction with neurons
dc.typeReview


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