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Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features

dc.contributor.authorListyarifah D.
dc.contributor.authorNieminen M.T.
dc.contributor.authorMäkinen L.K.
dc.contributor.authorHaglund C.
dc.contributor.authorGrenier D.
dc.contributor.authorHäyry V.
dc.contributor.authorNordström D.
dc.contributor.authorHernandez M.
dc.contributor.authorYucel-Lindberg T.
dc.contributor.authorTervahartiala T.
dc.contributor.authorAinola M.
dc.contributor.authorSorsa T.
dc.contributor.authorHagström J.
dc.date.accessioned2020-09-02T22:21:46Z
dc.date.available2020-09-02T22:21:46Z
dc.date.issued2018
dc.identifier10.1111/jop.12729
dc.identifier.citation47, 8, 764-772
dc.identifier.issn09042512
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5089
dc.descriptionBackground: Certain periodontopathogenic bacteria have been linked to cancers. Treponema denticola (Td) is associated with severe periodontitis. Chymotrypsin-like proteinase (CTLP), a major virulence factor of Td, can degrade various host proteins and peptides, and modulate inflammatory responses. However, the role of Td in the tongue carcinogenesis remains unknown. This study aimed to investigate the presence of Td-CTLP in early-stage mobile tongue squamous cell carcinoma (MTSCC) and its relation to clinical and pathological characteristics. Methods: The immunopositivity of Td-CTLP was assessed in samples obtained from 60 patients with MTSCC and associated with their clinicopathological data. Additionally, Td-CTLP expression was compared with immunoexpression of matrix metalloproteinases (MMP-8 and MMP-9), toll-like receptors (TLR-2, TLR-4, TLR-7 and TLR-9), c-Myc, Ki-67, Bmi-1 and Snail. Results: Treponema denticola-chymotrypsin-like proteinase was present in 95% of MTSCC tumours of which many (40.4%) showed high immunopositivity. Td-CTLP positivity was significantly associated with invasion depth, tumour diameter and the expression of TLR-7, TLR-9 and c-Myc. High Td-CTLP immunopositivity in younger patients (≤ 60 years old) predicted early relapse. Conclusion: Our data indicate that Td and its CTLP are present in early-stage MTSCC carcinoma and may contribute to carcinogenesis, and therefore provide novel perspectives into intervention and therapeutic measures of MTSCC. © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectchymotrypsin-like proteinase
dc.subjectmatrix metalloproteinase
dc.subjectmobile tongue squamous cell carcinoma
dc.subjecttoll-like receptor
dc.subjectTreponema denticola
dc.subjectchymotrypsin like proteinase
dc.subjectgelatinase B
dc.subjectKi 67 antigen
dc.subjectMyc protein
dc.subjectneutrophil collagenase
dc.subjectproteinase
dc.subjecttoll like receptor 2
dc.subjecttoll like receptor 4
dc.subjecttoll like receptor 7
dc.subjecttoll like receptor 9
dc.subjecttranscription factor Snail
dc.subjectunclassified drug
dc.subjectchymotrypsin
dc.subjectmatrix metalloproteinase
dc.subjectMyc protein
dc.subjectMYC protein, human
dc.subjectpeptide hydrolase
dc.subjecttoll like receptor
dc.subjectvirulence factor
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectcancer recurrence
dc.subjectcancer size
dc.subjectcancer staging
dc.subjectclinical feature
dc.subjectdisease association
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmobile tongue squamous cell carcinoma
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjecttongue carcinoma
dc.subjectTreponema denticola
dc.subjecttumor invasion
dc.subjectcomplication
dc.subjectenzymology
dc.subjectimmunohistochemistry
dc.subjectmetabolism
dc.subjectmicrobiology
dc.subjectmiddle aged
dc.subjectpathogenicity
dc.subjectpathology
dc.subjectperiodontitis
dc.subjectprotein degradation
dc.subjectsquamous cell carcinoma
dc.subjecttongue tumor
dc.subjectAged
dc.subjectCarcinoma, Squamous Cell
dc.subjectChymotrypsin
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMatrix Metalloproteinases
dc.subjectMiddle Aged
dc.subjectNeoplasm Invasiveness
dc.subjectNeoplasm Staging
dc.subjectPeptide Hydrolases
dc.subjectPeriodontitis
dc.subjectProteolysis
dc.subjectProto-Oncogene Proteins c-myc
dc.subjectToll-Like Receptors
dc.subjectTongue Neoplasms
dc.subjectTreponema denticola
dc.subjectVirulence Factors
dc.titleTreponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features
dc.typeArticle


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