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Ibuprofen intake increases exercise time to exhaustion: A possible role for preventing exercise-induced fatigue

dc.contributor.authorLima F.D.
dc.contributor.authorStamm D.N.
dc.contributor.authorDella Pace I.D.
dc.contributor.authorRibeiro L.R.
dc.contributor.authorRambo L.M.
dc.contributor.authorBresciani G.
dc.contributor.authorFerreira J.
dc.contributor.authorRossato M.F.
dc.contributor.authorSilva M.A.
dc.contributor.authorPereira M.E.
dc.contributor.authorIneu R.P.
dc.contributor.authorSantos A.R.
dc.contributor.authorBobinski F.
dc.contributor.authorFighera M.R.
dc.contributor.authorRoyes L.F.F.
dc.date.accessioned2020-09-02T22:21:44Z
dc.date.available2020-09-02T22:21:44Z
dc.date.issued2016
dc.identifier10.1111/sms.12549
dc.identifier.citation26, 10, 1160-1170
dc.identifier.issn09057188
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5080
dc.descriptionAlthough the intake of nonsteroidal anti-inflammatory drugs (NSAIDs) intake by athletes prevents soreness, little is known concerning their role in exercise performance. This study assessed the effects of ibuprofen intake on an exhaustive protocol test after 6 weeks of swimming training in rats. Animals were divided into sedentary and training groups. After training, animals were subdivided into two subsets: saline or ibuprofen. Afterwards, three repeated swimming bouts were performed by the groups. Ibuprofen (15 mg/kg) was administered once a day. Pain measurements were performed and inflammatory and oxidative stress parameters were assayed in cerebral cortex and gastrocnemius muscle. Training, ibuprofen administration, or both combined (P < 0.05; 211 ± 18s, 200 ± 31s, and 279 ± 23s) increased exercise time to exhaustion. Training decreased the acetylcholinesterase (AChE) activity (P < 0.05; 149 ± 11) in cerebral cortex. Ibuprofen intake decreased the AChE activity after exhaustive protocol test in trained and sedentary rats (P < 0.05; 270 ± 60; 171 ± 38; and 273 ± 29). It also prevented neuronal tumor necrosis factor-α (TNF-α) and interleukin (IL 1β) increase. Fatigue elicited by this exhaustive protocol may involve disturbances of the central nervous system. Additive anti-inflammatory effects of exercise and ibuprofen intake support the hypothesis that this combination may constitute a more effective approach. In addition, ergogenic aids may be a useful means to prevent exercise-induced fatigue. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
dc.language.isoen
dc.publisherBlackwell Munksgaard
dc.subjectAChE activity
dc.subjectExercise training
dc.subjectexhaustive exercise
dc.subjectinflammation
dc.subjectNSAIDs intake
dc.subjectacetylcholinesterase
dc.subjectibuprofen
dc.subjectinterleukin 1beta
dc.subjectnonsteroid antiinflammatory agent
dc.subjectreactive oxygen metabolite
dc.subjecttumor necrosis factor
dc.subjectanimal
dc.subjectanimal experiment
dc.subjectbrain cortex
dc.subjectdrug effects
dc.subjectendurance
dc.subjectfatigue
dc.subjectmale
dc.subjectmetabolism
dc.subjectnerve cell
dc.subjectoxidative stress
dc.subjectpain
dc.subjectpain measurement
dc.subjectphysiology
dc.subjectprotein carbonylation
dc.subjectrandomization
dc.subjectrat
dc.subjectskeletal muscle
dc.subjectswimming
dc.subjectWistar rat
dc.subjectAcetylcholinesterase
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectCerebral Cortex
dc.subjectFatigue
dc.subjectIbuprofen
dc.subjectInterleukin-1beta
dc.subjectMale
dc.subjectMuscle, Skeletal
dc.subjectNeurons
dc.subjectOxidative Stress
dc.subjectPain
dc.subjectPain Measurement
dc.subjectPhysical Conditioning, Animal
dc.subjectPhysical Endurance
dc.subjectProtein Carbonylation
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReactive Oxygen Species
dc.subjectSwimming
dc.subjectTumor Necrosis Factor-alpha
dc.titleIbuprofen intake increases exercise time to exhaustion: A possible role for preventing exercise-induced fatigue
dc.typeArticle


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