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Microglial dependent protective effects of neuroactive steroids

dc.contributor.authorLanussa O.H.
dc.contributor.authorÁvila-Rodriguez M.
dc.contributor.authorGarcía-Segura L.M.
dc.contributor.authorGonzález J.
dc.contributor.authorEcheverria V.
dc.contributor.authorAliev G.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:21:14Z
dc.date.available2020-09-02T22:21:14Z
dc.date.issued2016
dc.identifier10.2174/1871527315666160202122032
dc.identifier.citation15, 2, 242-249
dc.identifier.issn18715273
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5040
dc.descriptionMicroglial cells are extremely important for homeostasis of the CNS. Upon brain damage, microglia become reactive in response to inflammatory stimuli and lead to the secretion of inflammatory cytokines. Because microglia have the ability of adjusting their steady state to an active phenotype that modulates the CNS environment, chronic activation of microglia has an important role in mediating neuroinflammatory brain diseases. Depending upon the nature and degree of the injury stimulus, microglial activity may alternate, either to acute and mild responses -sometimes beneficial- or chronic and severe that may result in neurodegeneration. In this context, proper and controlled activation of microglia should be considered as a potential neuroprotective strategy against neurodegeneration. More recently, the use of estrogenic compounds to regulate microgliosis has shown promising results, and is currently being investigated due to their potential pharmacologic ability in the regulation of inflammation. In this review, we highlight the role of microgliamediated damage and discuss the effect of neurosteroids in reducing the adverse impact of inflammation in the brain. © 2016 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers
dc.subjectBrain damage
dc.subjectMicroglia
dc.subjectNeurodegeneration
dc.subjectNeuroinflammation
dc.subjectNeuroprotection
dc.subjectNeurosteroids
dc.subjectinterleukin 1
dc.subjectinterleukin 6
dc.subjectsteroid
dc.subjecttumor necrosis factor alpha
dc.subjectagents interacting with transmitter, hormone or drug receptors
dc.subjectcytokine
dc.subjectneuroprotective agent
dc.subjectreactive oxygen metabolite
dc.subjectbrain damage
dc.subjectcytokine production
dc.subjecthuman
dc.subjectimmune response
dc.subjectmicroglia
dc.subjectnerve degeneration
dc.subjectnervous system inflammation
dc.subjectneurotoxicity
dc.subjectoxidative stress
dc.subjectprotein phosphorylation
dc.subjectReview
dc.subjectsynaptic transmission
dc.subjectanimal
dc.subjectBrain Injuries
dc.subjectcellular immunity
dc.subjectdrug effects
dc.subjectimmunology
dc.subjectmacrophage activation
dc.subjectmetabolism
dc.subjectmicroglia
dc.subjectNeurodegenerative Diseases
dc.subjectphysiology
dc.subjectAnimals
dc.subjectBrain Injuries
dc.subjectCytokines
dc.subjectHumans
dc.subjectImmunity, Cellular
dc.subjectMacrophage Activation
dc.subjectMicroglia
dc.subjectNeurodegenerative Diseases
dc.subjectNeuroprotective Agents
dc.subjectNeurotransmitter Agents
dc.subjectReactive Oxygen Species
dc.titleMicroglial dependent protective effects of neuroactive steroids
dc.typeReview


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