Mostrar el registro sencillo del ítem

Curcumin as a therapeutic agent in leukemia

dc.contributor.authorKouhpeikar H.
dc.contributor.authorButler A.E.
dc.contributor.authorBamian F.
dc.contributor.authorBarreto G.E.
dc.contributor.authorMajeed M.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:21:08Z
dc.date.available2020-09-02T22:21:08Z
dc.date.issued2019
dc.identifier10.1002/jcp.28072
dc.identifier.citation234, 8, 12404-12414
dc.identifier.issn00219541
dc.identifier.urihttps://hdl.handle.net/20.500.12728/5008
dc.descriptionLeukemia comprises a group of hematological malignancies responsible for 8% of all cancers and is the most common cancer in children. Despite significant improvements in leukemia treatment, the efficacy of conventional chemotherapeutic agents is low and the disease carries a poor prognosis with frequent relapses and high mortality. Curcumin is a yellow polyphenol compound with diverse pharmacological actions including anticancer, antioxidant, antidiabetic, anti-inflammatory, immunomodulatory, hepatoprotective, lipid-regulating, antidepressant, and antiarthritic. Many cellular and experimental studies have reported the benefits of curcumin in treating leukemia. Curcumin's anticancer effects are exerted via various mechanisms. Here, we review the effects of curcumin on various types of leukemia whilst considering its mechanisms of action. © 2019 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherWiley-Liss Inc.
dc.subjectcancer
dc.subjectchemotherapeutic agents
dc.subjectcurcumin
dc.subjectleukemia
dc.subjectWilms' tumor 1 (WT1)
dc.subjectcurcumin
dc.subjectWT1 protein
dc.subjectantiinflammatory agent
dc.subjectantineoplastic agent
dc.subjectcurcumin
dc.subjectacute lymphoblastic leukemia
dc.subjectacute myeloid leukemia
dc.subjectantiinflammatory activity
dc.subjectantineoplastic activity
dc.subjectantioxidant activity
dc.subjectcancer chemotherapy
dc.subjectchronic lymphatic leukemia
dc.subjectchronic myeloid leukemia
dc.subjectclinical trial (topic)
dc.subjectdrug mechanism
dc.subjectgene expression
dc.subjecthuman
dc.subjectleukemia
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectReview
dc.subjectchild
dc.subjectleukemia
dc.subjecttreatment outcome
dc.subjectAnti-Inflammatory Agents
dc.subjectAntineoplastic Agents
dc.subjectChild
dc.subjectCurcumin
dc.subjectHumans
dc.subjectLeukemia
dc.subjectTreatment Outcome
dc.titleCurcumin as a therapeutic agent in leukemia
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-85059592660.pdf
Tamaño:
2.977Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem