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Sex differences in Parkinson's disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics

dc.contributor.authorJurado-Coronel J.C.
dc.contributor.authorCabezas R.
dc.contributor.authorÁvila Rodríguez M.F.
dc.contributor.authorEcheverria V.
dc.contributor.authorGarcía-Segura L.M.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:21:02Z
dc.date.available2020-09-02T22:21:02Z
dc.date.issued2018
dc.identifier10.1016/j.yfrne.2017.09.002
dc.identifier.citation50, , 18-30
dc.identifier.issn00913022
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4986
dc.descriptionParkinson's disease (PD) is the second most frequent age-related neurodegenerative disorder. Sex is an important factor in the development of PD, as reflected by the fact that it is more common in men than in women by an approximate ratio of 2:1. Our hypothesis is that differences in PD among men and women are highly determined by sex-dependent differences in the nigrostriatal dopaminergic system, which arise from environmental, hormonal and genetic influences. Sex hormones, specifically estrogens, influence PD pathogenesis and might play an important role in PD differences between men and women. The objective of this review was to discuss the PD physiopathology and point out sex differences in nigrostriatal degeneration, symptoms, genetics, responsiveness to treatments and biochemical and molecular mechanisms among patients suffering from this disease. Finally, we discuss the role estrogens may have on PD sex differences. © 2017 Elsevier Inc.
dc.language.isoen
dc.publisherAcademic Press Inc.
dc.subject6-OHDA
dc.subjectEstradiol
dc.subjectMotor symptoms
dc.subjectMPTP
dc.subjectNigrostriatal degeneration
dc.subjectNon-motor symptoms
dc.subjectParkinson's disease
dc.subjectSex
dc.subjectestrogen
dc.subjectlevodopa
dc.subjectsex hormone
dc.subjectsex hormone
dc.subjectbrain depth stimulation
dc.subjectdopaminergic system
dc.subjectgene expression profiling
dc.subjectgenetics
dc.subjectheredity
dc.subjecthuman
dc.subjectinflammation
dc.subjectmitochondrion
dc.subjectmolecular mechanics
dc.subjectnonhuman
dc.subjectparasomnia
dc.subjectParkinson disease
dc.subjectpathogenesis
dc.subjectpriority journal
dc.subjectReview
dc.subjectsex difference
dc.subjectstriatonigral degeneration
dc.subjectsymptom
dc.subjecttreatment outcome
dc.subjectanimal
dc.subjectfemale
dc.subjectmale
dc.subjectmetabolism
dc.subjectoutcome assessment
dc.subjectParkinson disease
dc.subjectpathophysiology
dc.subjectsexual characteristics
dc.subjectAnimals
dc.subjectFemale
dc.subjectGonadal Steroid Hormones
dc.subjectHumans
dc.subjectMale
dc.subjectOutcome Assessment (Health Care)
dc.subjectParkinson Disease
dc.subjectSex Characteristics
dc.titleSex differences in Parkinson's disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics
dc.typeReview


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