Mostrar el registro sencillo del ítem

Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease

dc.contributor.authorIturriaga R.
dc.contributor.authorDel Rio R.
dc.contributor.authorIdiaquez J.
dc.contributor.authorSomers V.K.
dc.date.accessioned2020-09-02T22:20:40Z
dc.date.available2020-09-02T22:20:40Z
dc.date.issued2016
dc.identifier10.1186/s40659-016-0073-8
dc.identifier.citation49, 1, -
dc.identifier.issn07169760
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4957
dc.descriptionThe carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. © 2016 The Author(s).
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.subjectAutonomic dysfunction
dc.subjectCarotid body
dc.subjectHeart failure
dc.subjectMetabolic syndrome
dc.subjectObstructive sleep apnea
dc.subjectSympathetic activation
dc.subjectadrenergic system
dc.subjectcarotid body
dc.subjectchemistry
dc.subjectheart failure
dc.subjecthuman
dc.subjectMetabolic Diseases
dc.subjectpathophysiology
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectrisk factor
dc.subjectSleep Apnea, Obstructive
dc.subjectCarotid Body
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectMetabolic Diseases
dc.subjectPulmonary Disease, Chronic Obstructive
dc.subjectRisk Factors
dc.subjectSleep Apnea, Obstructive
dc.subjectSympathetic Nervous System
dc.titleCarotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84994815486.pdf
Tamaño:
2.797Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem