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Crucial role of the carotid body chemoreceptors on the development of high arterial blood pressure during chronic intermittent hypoxia

dc.contributor.authorIturriaga R.
dc.contributor.authorAndrade D.C.
dc.contributor.authorDel Rio R.
dc.date.accessioned2020-09-02T22:20:39Z
dc.date.available2020-09-02T22:20:39Z
dc.date.issued2015
dc.identifier10.1007/978-3-319-18440-1_29
dc.identifier.citation860, , 255-260
dc.identifier.issn00652598
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4955
dc.descriptionExposure to chronic intermittent hypoxia (CIH), the main feature of obstructive sleep apnea, produces autonomic and cardiorespirartory alterations, and leads to systemic hypertension. These alterations are associated with enhanced carotid body (CB) chemosensory and ventilatory hypoxic reflexes and a decrease baroreflex (BRS) efficiency. The aim of this study was to determine the therapeutic effect of CB ablation on the elevated arterial blood pressure, the reduced BRS and the potentiated ventilatory response induced by CIH in conscious rats. Arterial blood pressure (BP) was continuous measured by telemetry in male Sprague-Dawley rats exposed to CIH (5 % O<inf>2</inf>, 12 times/h, and 8 h/day). After 21 days of CIH, the CBs were selectively cryodestroyed, and rats were kept one more week in CIH. Ventilatory responses to hypoxia were assessed by whole body plethysmography and spontaneous BRS measured by the sequence method. Exposure to CIH produces hypertension, increased the chemoreflex ventilatory hypoxic responses, and decreased BRS. The ablation of the CBs normalized the elevated BP, and the altered ventilatory response and BRS. Present results suggest that the CB play a crucial role in the development of high arterial pressure and autonomic alterations induced by CIH. © Springer International Publishing Switzerland 2015.
dc.language.isoen
dc.publisherSpringer New York LLC
dc.subjectBaroreflex
dc.subjectCarotid body
dc.subjectChemoreflex
dc.subjectIntermittent hypoxia
dc.subjectObstructive sleep apnea
dc.subjectablation therapy
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarterial pressure
dc.subjectArticle
dc.subjectautonomic neuropathy
dc.subjectbody plethysmography
dc.subjectcarotid body chemoreceptor
dc.subjectchronic intermittent hypoxia
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectenvironmental exposure
dc.subjecthypertension
dc.subjectlung function
dc.subjectmale
dc.subjectnonhuman
dc.subjectpressoreceptor reflex
dc.subjectpriority journal
dc.subjectrat
dc.subjecttelemetry
dc.subjecttidal volume
dc.subjecttreatment response
dc.subjectventilatory hypoxic response
dc.subjectanimal
dc.subjectanoxia
dc.subjectcarotid body
dc.subjectchronic disease
dc.subjecthypertension
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectreflex
dc.subjectSprague Dawley rat
dc.subjectBovine respiratory syncytial virus
dc.subjectRattus
dc.subjectAnimals
dc.subjectAnoxia
dc.subjectCarotid Body
dc.subjectChronic Disease
dc.subjectHypertension
dc.subjectMale
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectReflex
dc.titleCrucial role of the carotid body chemoreceptors on the development of high arterial blood pressure during chronic intermittent hypoxia
dc.typeArticle


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