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Acquisition, maintenance and relapse-like alcohol drinking: Lessons from the uchb rat line
dc.contributor.author | Israel Y. | |
dc.contributor.author | Karahanian E. | |
dc.contributor.author | Ezquer F. | |
dc.contributor.author | Morales P. | |
dc.contributor.author | Ezquer M. | |
dc.contributor.author | Rivera-Meza M. | |
dc.contributor.author | Herrera-Marschitz M. | |
dc.contributor.author | Quintanilla M.E. | |
dc.date.accessioned | 2020-09-02T22:20:39Z | |
dc.date.available | 2020-09-02T22:20:39Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.3389/fnbeh.2017.00057 | |
dc.identifier.citation | 11, , - | |
dc.identifier.issn | 16625153 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/4953 | |
dc.description | This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the maintenance of chronic alcohol intake; and (iii) alcohol relapse-like drinking behavior in animals bred for their high-ethanol intake. Data from several rat strains/lines strongly suggest that catalase-mediated brain oxidation of ethanol into acetaldehyde is an absolute requirement (up 80%–95%) for rats to display ethanol’s reinforcing effects and to initiate chronic ethanol intake. Acetaldehyde binds non-enzymatically to dopamine forming salsolinol, a compound that is selfadministered. In UChB rats, salsolinol: (a) generates marked sensitization to the motivational effects of ethanol; and (b) strongly promotes binge-like drinking. The specificity of salsolinol actions is shown by the finding that only the R-salsolinol enantiomer but not S-salsolinol accounted for the latter effects. Inhibition of brain acetaldehyde synthesis does not influence the maintenance of chronic ethanol intake. However, a prolonged ethanol withdrawal partly returns the requirement for acetaldehyde synthesis/levels both on chronic ethanol intake and on alcohol relapse-like drinking. Chronic ethanol intake, involving the action of lipopolysaccharide diffusing from the gut, and likely oxygen radical generated upon catechol/salsolinol oxidation, leads to oxidative stress and neuro-inflammation, known to potentiate each other. Data show that the administration of N-acetyl cysteine (NAC) a strong antioxidant inhibits chronic ethanol maintenance by 60%–70%, without inhibiting its initial intake. Intracerebroventricular administration of mesenchymal stem cells (MSCs), known to release anti-inflammatory cytokines, to elevate superoxide dismutase levels and to reverse ethanol-induced hippocampal injury and cognitive deficits, also inhibited chronic ethanol maintenance; further, relapse-like ethanol drinking was inhibited up to 85% for 40 days following intracerebral stem cell administration. Thus: (i) ethanol must be metabolized intracerebrally into acetaldehyde, and further into salsolinol, which appear responsible for promoting the acquisition of the early reinforcing effects of ethanol; (ii) acetaldehyde is not responsible for the maintenance of chronic ethanol intake, while other mechanisms are indicated; (iii) the systemic administration of NAC, a strong antioxidant markedly inhibits the maintenance of chronic ethanol intake; and (iv) the intra-cerebroventricular administration of anti-inflammatory and antioxidant MSCs inhibit both the maintenance of chronic ethanol intake and relapse-like drinking. © 2017 Israel, Karahanian, Ezquer, Morales, Ezquer, Rivera-Meza, Herrera-Marschitz and Quintanilla. | |
dc.language.iso | en | |
dc.publisher | Frontiers Media S.A. | |
dc.subject | Acetaldehyde | |
dc.subject | Catalase | |
dc.subject | Ethanol | |
dc.subject | Inflammation | |
dc.subject | Reactive oxygen species | |
dc.subject | Reinforcement (psychology) | |
dc.subject | Relapse | |
dc.subject | Stem cells | |
dc.subject | acetaldehyde | |
dc.subject | acetylcysteine | |
dc.subject | alcohol | |
dc.subject | catalase | |
dc.subject | dopamine | |
dc.subject | salsolinol | |
dc.subject | alcohol consumption | |
dc.subject | alcohol withdrawal syndrome | |
dc.subject | aversion | |
dc.subject | binge drinking | |
dc.subject | drinking behavior | |
dc.subject | mesenchymal stem cell | |
dc.subject | nervous system inflammation | |
dc.subject | nonhuman | |
dc.subject | oxidative stress | |
dc.subject | rat | |
dc.subject | rat strain | |
dc.subject | reinforcement | |
dc.subject | relapse | |
dc.subject | Review | |
dc.title | Acquisition, maintenance and relapse-like alcohol drinking: Lessons from the uchb rat line | |
dc.type | Review |