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Loss of ZNF516 protein expression is related with HR-HPV infection and cervical preneoplastic lesions

dc.contributor.authorIli C.
dc.contributor.authorLopez J.
dc.contributor.authorBuchegger K.
dc.contributor.authorRiquelme I.
dc.contributor.authorRetamal J.
dc.contributor.authorZanella L.
dc.contributor.authorMora-Lagos B.
dc.contributor.authorVivallo C.
dc.contributor.authorRoa J.C.
dc.contributor.authorBrebi P.
dc.date.accessioned2020-09-02T22:20:35Z
dc.date.available2020-09-02T22:20:35Z
dc.date.issued2019
dc.identifier10.1007/s00404-018-5012-1
dc.identifier.citation299, 4, 1099-1108
dc.identifier.issn09320067
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4930
dc.descriptionPurpose: Cervical cancer is an important health issue among women worldwide. Cervical smear and human papillomavirus detection are the most used screening methods to detect preneoplastic and neoplastic lesions. However, as neither can predict cervical development, new markers are needed for this disease. ZNF516, a potential tumor suppressor gene, has been found altered in cervical cancer. The objective of this study was to determine ZNF516 immunohistochemistry frequency in cervical biopsies and its association with clinicopathological parameters, to evaluate its potential as marker in cervical lesions. Methods: A retrospective series of 452 formalin-fixed, paraffin-embedded (FFPE) cervical biopsies, obtained between 2002 and 2007, were selected for immunohistochemistry of ZNF516, p16 and Ki-67 markers. Human papillomavirus genotyping was performed on 272 of these samples through reverse line blot assay. Results: An inverse relation between ZNF516 expression and cervical lesions grade (P < 0.001) was observed, given this protein was found mainly expressed in normal tissues, while was decreased in cervical lesions. As expected, the proliferation markers p16 and Ki-67 were found highly expressed in cervical cancer compared to normal tissues, and inversely correlated to ZNF516 expression (P < 0.01). High oncogenic risk-Human papillomavirus presence also was related to the lack of ZNF516 expression in cervical lesions (P < 0.05), and the detection of these two parameters showed a high sensitivity (70.9%) for preneoplastic lesions detection. Conclusions: The loss of ZNF516 expression was found in cervical lesions, and its detection potentially could be used as a complementary marker of early diagnosis in cervical lesions. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subjectCervical cancer
dc.subjectHuman papillomavirus
dc.subjectImmunohistochemistry
dc.subjectKi-67
dc.subjectp16
dc.subjectZNF516
dc.subjectbiological marker
dc.subjectKi 67 antigen
dc.subjectprotein p16
dc.subjectunclassified drug
dc.subjectzinc finger protein
dc.subjectZNF516 protein
dc.subjectDNA binding protein
dc.subjecttumor marker
dc.subjectZNF516 protein, human
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectArticle
dc.subjectassay
dc.subjectcancer risk
dc.subjectclinical feature
dc.subjectclinical outcome
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectearly diagnosis
dc.subjectfemale
dc.subjectgenotype
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectmajor clinical study
dc.subjectpapillomavirus infection
dc.subjectprotein expression
dc.subjectretrospective study
dc.subjectreverse line blot assay
dc.subjectsquamous intraepithelial lesion of the cervix
dc.subjectuterine cervix biopsy
dc.subjectuterine cervix carcinoma
dc.subjectuterine cervix carcinoma in situ
dc.subjectchemistry
dc.subjectcomplication
dc.subjectmiddle aged
dc.subjectpapillomavirus infection
dc.subjectprecancer
dc.subjectuterine cervix tumor
dc.subjectvery elderly
dc.subjectvirology
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBiomarkers, Tumor
dc.subjectDNA-Binding Proteins
dc.subjectFemale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectPapillomavirus Infections
dc.subjectPrecancerous Conditions
dc.subjectRetrospective Studies
dc.subjectUterine Cervical Neoplasms
dc.subjectYoung Adult
dc.titleLoss of ZNF516 protein expression is related with HR-HPV infection and cervical preneoplastic lesions
dc.typeArticle


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