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Neurobehavioral and autonomic alterations in adults with obstructive sleep apnea

dc.contributor.authorIdiaquez J.
dc.contributor.authorSantos I.
dc.contributor.authorSantin J.
dc.contributor.authorDel Rio R.
dc.contributor.authorIturriaga R.
dc.date.accessioned2020-09-02T22:20:34Z
dc.date.available2020-09-02T22:20:34Z
dc.date.issued2014
dc.identifier10.1016/j.sleep.2014.05.030
dc.identifier.citation15, 11, 1319-1323
dc.identifier.issn13899457
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4927
dc.descriptionObjective: Obstructive sleep apnea (OSA) is associated with sympathetic hyperactivity, excessive nocturnal sweating, sleepiness, and neurobehavioral cognitive alterations. However, it is not well known if cognitive consequences of OSA are independent from autonomic alterations. Thus, we assessed the association between polysomnographic, autonomic, and cognitive tests performance in OSA patients. Methods: Fifty eight OSA patients (53 male) were administered with questionnaires assessing demographic, Epworth, Beck Depression Inventory, Syndrom Kurz test (SKT), Trail Making part B (TMT-B), and Frontal Assessment Battery (FAB) tests. Spectral analysis of heart rate variability (HRV) and night sweating symptoms (NSwS) score were used to assess autonomic function. Results: Global cognitive function (SKT) was normal in mild-moderate (M-OSA) and severe (S-OSA) patients. In S-OSA patients AHI was correlated with TMT-B (r = 0.30 P < 0.05) and with FAB (r = -0.31 P < 0.05). Oxygen desaturation was correlated with TMT-B (r = -0.45 P = < 0.001) and FAB (r = 0.29 P = < 0.05). Sympathetic overactivity was correlated with oxygen desaturation: HRV (r = -0.39 P < 0.05) and NSwS score (r = -0.49 P < 0.01), but HRV and NSwS score were not correlated with TMT-B and FAB. Conclusion: Frontal cognitive dysfunction and predominance of sympathetic drive occur in OSA patients. Abnormal frontal cognitive function and sympathetic hyperactivity were related to oxygen desaturation, but not between each other. We conclude that neurobehavioral changes and autonomic imbalance in OSA patients take place independently from each other, suggesting different pathophysiological pathways. © 2014 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectAutonomic dysfunction
dc.subjectCognitive dysfunction tests
dc.subjectHeart rate variability
dc.subjectNight sweating
dc.subjectObstructive sleep apnea
dc.subjectadolescent
dc.subjectadrenergic stimulation
dc.subjectadult
dc.subjectArticle
dc.subjectautonomic dysfunction
dc.subjectBeck Depression Inventory
dc.subjectcognition
dc.subjectcognitive defect
dc.subjectcorrelational study
dc.subjectdisease association
dc.subjectdisease severity
dc.subjectEpworth sleepiness scale
dc.subjectfemale
dc.subjectFrontal Assessment Battery test
dc.subjectheart rate variability
dc.subjecthuman
dc.subjecthyperactivity
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectneurologic examination
dc.subjectnight sweat
dc.subjectnight sweating symptoms score
dc.subjectoxygen desaturation
dc.subjectpsychologic test
dc.subjectquestionnaire
dc.subjectscoring system
dc.subjectsleep disordered breathing
dc.subjectsympathetic hyperactivity
dc.subjectSyndrom Kurz test
dc.subjectAutonomic Nervous System Diseases
dc.subjectCognition Disorders
dc.subjectcomplication
dc.subjectheart rate
dc.subjectmiddle aged
dc.subjectneuropsychological test
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectpolysomnography
dc.subjectsleep disordered breathing
dc.subjectAdult
dc.subjectAutonomic Nervous System Diseases
dc.subjectCognition Disorders
dc.subjectHeart Rate
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeuropsychological Tests
dc.subjectPolysomnography
dc.subjectSleep Apnea, Obstructive
dc.titleNeurobehavioral and autonomic alterations in adults with obstructive sleep apnea
dc.typeArticle


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