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Unsuspected intrinsic property of melanin to dissociate water can be used for the treatment of CNS diseases

dc.contributor.authorHerrera A.S.
dc.contributor.authorEsparza M.C.A.
dc.contributor.authorArias P.E.S.
dc.contributor.authorÁvila-Rodriguez M.
dc.contributor.authorBarreto G.E.
dc.contributor.authorLi Y.
dc.contributor.authorBachurin S.O.
dc.contributor.authorAliev G.
dc.date.accessioned2020-09-02T22:20:34Z
dc.date.available2020-09-02T22:20:34Z
dc.date.issued2016
dc.identifier10.2174/1871527315666160202122943
dc.identifier.citation15, 2, 135-140
dc.identifier.issn18715273
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4926
dc.descriptionRetinal adhesion mechanisms in mammals are quite complex and multifactorial in nature. To date, these mechanisms are incompletely understood due to a variety of chemical, physical, and physiological forces impinging upon retinal tissue: retinal pigment epithelium, nearby tissues as sclera and vitreous, the subretinal space, and the highly complex interphotoreceptor matrix that fills subretinal space. The adhesion of the retina to the choroid, rather than anatomical, is a dynamic process, as the retina detaches a few minutes after life ceases. The adhesion mechanisms described in the literature, such as intraocular pressure and the oncotic pressure of the choroid that seems to push the retina towards the choroid, the delicate anatomical relationships between the rod and cone photoreceptors, the retinal pigment epithelium, the existence of a complex material called interphotoreceptor matrix, as well as other metabolic and structural factors, still cannot explain the remarkable features observed in the adhesion mechanisms between the photoreceptor layer and retinal pigment epithelium cells. The unexpected intrinsic property of melanin to absorb light energy and transform it into chemically based free energy can explain normal adhesion of the sensory retina to the pigment epithelium. In this article, we explore and highlight this explanation, which states that it is definitely able to provide a new treatment avenue against devastating neurodegenerative properties. © 2016 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers
dc.subjectMelanin
dc.subjectOncotic pressure
dc.subjectPharmacological effects
dc.subjectPhotoreceptors
dc.subjectQIAPI-1- (Medical enhancer of human photosynthesis or chemical energy modulator)
dc.subjectRetina
dc.subjectmelanin
dc.subjectmelanin
dc.subjectwater
dc.subjectage related macular degeneration
dc.subjectArticle
dc.subjectblood flow
dc.subjectcentral nervous system disease
dc.subjectcirculation
dc.subjectconceptual framework
dc.subjecteye movement
dc.subjecthuman
dc.subjectintraocular pressure
dc.subjectintrinsic activity
dc.subjectoncotic pressure
dc.subjectpigment epithelium
dc.subjectvitreous body
dc.subjectanimal
dc.subjectCentral Nervous System Diseases
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectretina
dc.subjecttreatment outcome
dc.subjectAnimals
dc.subjectCentral Nervous System Diseases
dc.subjectHumans
dc.subjectMelanins
dc.subjectRetina
dc.subjectTreatment Outcome
dc.subjectWater
dc.titleUnsuspected intrinsic property of melanin to dissociate water can be used for the treatment of CNS diseases
dc.typeArticle


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