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Synthesis, crystal structure, catalytic and anti-Trypanosoma cruzi activity of a new chromium(III) complex containing bis(3,5-dimethylpyrazol-1-yl)methane

dc.contributor.authorHurtado J.
dc.contributor.authorIbarra L.
dc.contributor.authorYepes D.
dc.contributor.authorGarcía-Huertas P.
dc.contributor.authorMacías M.A.
dc.contributor.authorTriana-Chavez O.
dc.contributor.authorNagles E.
dc.contributor.authorSuescun L.
dc.contributor.authorMuñoz-Castro A.
dc.date.accessioned2020-09-02T22:20:33Z
dc.date.available2020-09-02T22:20:33Z
dc.date.issued2017
dc.identifier10.1016/j.molstruc.2017.06.014
dc.identifier.citation1146, , 365-372
dc.identifier.issn00222860
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4919
dc.descriptionThe reaction of CrCl36H2O with the ligand bis(3,5-dimethylpyrazol-1-yl)methane (L) yielded the cationic complex [(Cr(L)(H2O)2Cl2]+, which crystallized as the chloride trihydrate [(Cr(L)(H2O)2Cl2]Cl·3H2O. The chromium complex was characterized by elemental analysis, electrical conductivity, Infrared and Ultraviolet/Visible spectroscopy. The crystal structure determination using single-crystal X-ray diffraction showed a chromium center in a distorted octahedral coordination sphere. In the crystal, the packing was directed by O[sbnd]H⋯(O,Cl) hydrogen bonds and weak C[sbnd]H⋯O interactions to build a monoclinic P21/c supramolecular structure. The complex showed excellent properties as an initiator for the ring opening polymerization of є-caprolactone (CL) under solvent-free conditions. The obtained polymer showed high crystallinity (89.9%) and a decomposition temperature above 475 °C. In addition, the new complex was evaluated against epimastigotes from Trypanosoma cruzi (T. cruzi) strains. The results indicated that this complex has a high activity against this parasite with a minimum inhibitory concentration 50 (MIC50) of 1.08 μg/mL. Interestingly, this compound showed little effect on erythrocytes, indicating that it is not cytotoxic. These results provide interesting contributions to the design of metal complexes by using simple and accessible ligands with activity against T. cruzi and with potential applications in the polymerization of CL. © 2017 Elsevier B.V.
dc.language.isoen
dc.publisherElsevier B.V.
dc.subjectChromium complex
dc.subjectCrystal structure
dc.subjectRing opening polymerization
dc.subjectTrypanosoma cruzi
dc.subjectε-caprolactone
dc.subjectChlorine compounds
dc.subjectChromium
dc.subjectChromium compounds
dc.subjectHydrogen bonds
dc.subjectLigands
dc.subjectMetal complexes
dc.subjectMethane
dc.subjectPolymerization
dc.subjectRing opening polymerization
dc.subjectSingle crystals
dc.subjectX ray diffraction
dc.subjectCaprolactone
dc.subjectChromium complexes
dc.subjectCrystal structure determination
dc.subjectDecomposition temperature
dc.subjectMinimum inhibitory concentration
dc.subjectSingle crystal x-ray diffraction
dc.subjectSupramolecular structure
dc.subjectTrypanosoma cruzi
dc.subjectCrystal structure
dc.titleSynthesis, crystal structure, catalytic and anti-Trypanosoma cruzi activity of a new chromium(III) complex containing bis(3,5-dimethylpyrazol-1-yl)methane
dc.typeArticle


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