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Innate immune cells' contribution to systemic lupus erythematosus

dc.contributor.authorHerrada A.A.
dc.contributor.authorEscobedo N.
dc.contributor.authorIruretagoyena M.
dc.contributor.authorValenzuela R.A.
dc.contributor.authorBurgos P.I.
dc.contributor.authorCuitino L.
dc.contributor.authorLlanos C.
dc.date.accessioned2020-09-02T22:20:29Z
dc.date.available2020-09-02T22:20:29Z
dc.date.issued2019
dc.identifier10.3389/fimmu.2019.00772
dc.identifier.citation10, MAR, -
dc.identifier.issn16643224
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4893
dc.descriptionSystemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens, immune complex deposition, and tissue damage in the kidneys, skin, heart and lung. Because of the pathogenic role of antinuclear antibodies and autoreactive T cells in SLE, extensive efforts have been made to demonstrate how B cells act as antibody-producing or as antigen-presenting cells that can prime autoreactive T cell activation. With the discovery of new innate immune cells and inflammatory mediators, innate immunity is emerging as a key player in disease pathologies. Recent work over the last decade has highlighted the importance of innate immune cells and molecules in promoting and potentiating SLE. In this review, we discuss recent evidence of the involvement of different innate immune cells and pathways in the pathogenesis of SLE. We also discuss new therapeutics targets directed against innate immune components as potential novel therapies in SLE. Copyright © 2019 Herrada, Escobedo, Iruretagoyena, Valenzuela, Burgos, Cuitino and Llanos.
dc.language.isoen
dc.publisherFrontiers Media S.A.
dc.subjectDendritic cells
dc.subjectInnate immunity
dc.subjectInnate lymphoid cell
dc.subjectLupus (SLE)
dc.subjectMacrophage-cell
dc.subjectantinuclear antibody
dc.subjectcell nucleus antigen
dc.subjectcytokine
dc.subjecttoll like receptor
dc.subjectantigen presenting cell
dc.subjectB lymphocyte
dc.subjectbasophil
dc.subjectcomplement system
dc.subjectdendritic cell
dc.subjecthuman
dc.subjectimmunocompetent cell
dc.subjectinnate immunity
dc.subjectlymphoid cell
dc.subjectmacrophage
dc.subjectmediator
dc.subjectneutrophil
dc.subjectReview
dc.subjectsystemic lupus erythematosus
dc.subjectT lymphocyte
dc.subjectT lymphocyte activation
dc.titleInnate immune cells' contribution to systemic lupus erythematosus
dc.typeReview


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