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Influence of Intravenous Nitrate Treatment on Early Mortality among Patients with Acute Heart Failure. NITRO-EAHFE Study [Influencia del tratamiento con nitratos intravenosos en la mortalidad precoz de pacientes con insuficiencia cardiaca aguda. Estudio NITRO-EAHFE]

dc.contributor.authorHerrero-Puente P.
dc.contributor.authorJacob J.
dc.contributor.authorMartín-Sánchez F.J.
dc.contributor.authorVázquez-Álvarez J.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorMiró Ò.
dc.contributor.authorLucas-Imbernón F.J.
dc.contributor.authorMartínez-Zapico A.
dc.contributor.authorLlorens P.
dc.date.accessioned2020-09-02T22:20:28Z
dc.date.available2020-09-02T22:20:28Z
dc.date.issued2015
dc.identifier10.1016/j.recesp.2014.12.017
dc.identifier.citation68, 11, 959-967
dc.identifier.issn03008932
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4885
dc.descriptionIntroduction and objectives There is little evidence on the prognostic influence of intravenous nitrates in patients with acute heart failure. Our purpose was to determine the influence of this treatment on early mortality and new visits. Methods Prospective, multicenter cohort study of patients with acute heart failure in an emergency room during 2 periods (May 2009 and November-December 2011). Patients with systolic blood pressure > 110 mmHg were included, grouped according to whether they received intravenous nitroglycerin or not. Endpoints were mortality at 3, 7, 14, and 30 days and new visits at 30 days. The propensity score was estimated by logistic regression to determine the prognostic influence of the treatment. Results We included 3178 of 4897 individuals. A total of 308 (9.7%) had died within 30 days and 465 (17%) attended new visits. The mean (standard deviation) age was 79.5 (10.0) years, and 796 (25%) patients received intravenous nitrates. After matching, there were 685 individuals in each group. The hazard ratio for 30-day mortality with nitrates was 1.21 (95% confidence interval, 0.87-1.70) and was 0.93 for new visits (95% confidence interval, 0.71-1.22). The results were similar for mortality at 3, 7, and 14 days (hazard ratio = 1.05 [95% confidence interval, 0.56-1.96], hazard ratio = 1.20 [95% confidence interval, 0.74-1.94], and hazard ratio = 1.23 [95% confidence interval, 0.82-1.84], respectively). In the presence of hypertensive pulmonary edema, the nitrates group showed a hazard ratio of 0.88 (95% confidence interval, 0.47-1.63) for 30-day mortality. Conclusions Intravenous nitrates do not influence early mortality or new visits in patients with acute heart failure. © 2014 Sociedad Española de Cardiología.
dc.language.isoes
dc.publisherEdiciones Doyma, S.L.
dc.subjectAcute heart failure
dc.subjectHospital emergency rooms
dc.subjectIntravenous nitrates
dc.subjectMortality
dc.subjectPropensity score
dc.subjectglyceryl trinitrate
dc.subjectnitrate
dc.subjectglyceryl trinitrate
dc.subjectnitric acid derivative
dc.subjectvasodilator agent
dc.subjectacute heart failure
dc.subjectArticle
dc.subjectclinical trial
dc.subjectcohort analysis
dc.subjectemergency care
dc.subjecthuman
dc.subjecthypertension
dc.subjectlung edema
dc.subjectmajor clinical study
dc.subjectmortality
dc.subjectprognosis
dc.subjectprospective study
dc.subjectsystolic blood pressure
dc.subjectaged
dc.subjectfemale
dc.subjectheart failure
dc.subjecthospital emergency service
dc.subjectintravenous drug administration
dc.subjectmale
dc.subjectmortality
dc.subjectproportional hazards model
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCohort Studies
dc.subjectEmergency Service, Hospital
dc.subjectFemale
dc.subjectHeart Failure
dc.subjectHumans
dc.subjectInfusions, Intravenous
dc.subjectMale
dc.subjectNitrates
dc.subjectNitroglycerin
dc.subjectPrognosis
dc.subjectProportional Hazards Models
dc.subjectProspective Studies
dc.subjectVasodilator Agents
dc.titleInfluence of Intravenous Nitrate Treatment on Early Mortality among Patients with Acute Heart Failure. NITRO-EAHFE Study [Influencia del tratamiento con nitratos intravenosos en la mortalidad precoz de pacientes con insuficiencia cardiaca aguda. Estudio NITRO-EAHFE]
dc.typeArticle


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