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Influence of sex on biomarkers of oxidative stress in the kidney, lungs, and liver of rabbits after exposure to diazinon

dc.contributor.authorHernández-Moreno D.
dc.contributor.authorMíguez M.P.
dc.contributor.authorSoler F.
dc.contributor.authorPérez-López M.
dc.date.accessioned2020-09-02T22:20:03Z
dc.date.available2020-09-02T22:20:03Z
dc.date.issued2018
dc.identifier10.1007/s11356-018-3258-6
dc.identifier.citation25, 32, 32458-32465
dc.identifier.issn09441344
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4856
dc.descriptionThe present study evaluated the effect of two oral doses of the pesticide diazinon (25 and 125 mg/kg bw) on four biochemical parameters (malondialdehyde and glutathione levels, and catalase and glutathione S-transferase enzymatic activities) in the kidney, lungs, and liver of rabbit after 10 days of exposure. Malondialdehyde levels were significantly greater in exposed animals compared to controls, especially in the animals exposed to the higher dose of the pesticide. This result was reflected in the glutathione levels, which were significantly lower at that same higher dose. Catalase activity was also inhibited by the higher dose of the pesticide in all three organs analysed, whereas inhibition of glutathione S-transferase activity was only significant for the kidney and lungs. There were some slight differences between the sexes: taking the results for all three organs, the higher dose of diazinon resulted in a clearly significant inhibitory effect on the catalase activity and glutathione levels in males, and a significant enhancing effect on the malondialdehyde levels in females. These results help to confirm the interest of considering such endogenous factors in future ecotoxicological studies, and that the four biomarkers considered are suitable for reflecting the toxic effects of diazinon on rabbits, especially the effects related to oxidative stress. [Figure not available: see fulltext.]. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subjectBiomarker
dc.subjectDiazinon
dc.subjectOrganophosphorus insecticide
dc.subjectOxidative stress
dc.subjectRabbit
dc.subjectAnimalia
dc.subjectOryctolagus cuniculus
dc.subjectantioxidant
dc.subjectbiological marker
dc.subjectcatalase
dc.subjectdimpylate
dc.subjectglutathione
dc.subjectglutathione peroxidase
dc.subjectglutathione transferase
dc.subjectinsecticide
dc.subjectmalonaldehyde
dc.subjectanimal
dc.subjectdrug effect
dc.subjectecotoxicology
dc.subjectfemale
dc.subjectkidney
dc.subjectLeporidae
dc.subjectliver
dc.subjectlung
dc.subjectmale
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectpollutant
dc.subjectsex factor
dc.subjecttoxicity
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectBiomarkers
dc.subjectCatalase
dc.subjectDiazinon
dc.subjectEcotoxicology
dc.subjectEnvironmental Pollutants
dc.subjectFemale
dc.subjectGlutathione
dc.subjectGlutathione Peroxidase
dc.subjectGlutathione Transferase
dc.subjectInsecticides
dc.subjectKidney
dc.subjectLiver
dc.subjectLung
dc.subjectMale
dc.subjectMalondialdehyde
dc.subjectOxidative Stress
dc.subjectRabbits
dc.subjectSex Factors
dc.titleInfluence of sex on biomarkers of oxidative stress in the kidney, lungs, and liver of rabbits after exposure to diazinon
dc.typeArticle


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