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Hesperidin as a neuroprotective agent: A review of animal and clinical evidence

dc.contributor.authorHajialyani M.
dc.contributor.authorFarzaei M.H.
dc.contributor.authorEcheverría J.
dc.contributor.authorNabavi S.M.
dc.contributor.authorUriarte E.
dc.contributor.authorEduardo S.-S.
dc.date.accessioned2020-09-02T22:20:00Z
dc.date.available2020-09-02T22:20:00Z
dc.date.issued2019
dc.identifier10.3390/molecules24030648
dc.identifier.citation24, 3, -
dc.identifier.issn14203049
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4839
dc.descriptionNeuroprotection is the preservation of function and networks of neural tissues from damages caused by various agents, as well as neurodegenerative diseases such as Parkinson’s, Alzheimer’s, Huntington’s diseases, and multiple sclerosis. Hesperidin, a flavanone glycoside, is a natural phenolic compound with a wide range of biological effects. Mounting evidence has demonstrated that hesperidin possesses inhibitory effect against development of neurodegenerative diseases. Our review discusses neuropharmacological mechanisms for preventive and therapeutic effects of hesperidin in neurodegenerative diseases. In addition, the review examines clinical evidence confirming its neuroprotective function. Various cellular and animal models specific to neurodegenerative diseases have been conducted to evaluate the underlying neuropharmacological mechanisms of hesperidin. Neuroprotective potential of this flavonoid is mediated by improvement of neural growth factors and endogenous antioxidant defense functions, diminishing neuro-inflammatory and apoptotic pathways. Despite the various preclinical studies on the role of hesperidin in the neurodegenerative diseases, less is known about its definite effect on humans. A limited number of clinical trials showed that hesperidin-enriched dietary supplements can significantly improve cerebral blood flow, cognition, and memory performance. Further clinical trials are also required for confirming neuroprotective efficacy of this natural flavonoid and evaluating its safety profile. © 2019 by the authors.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectAlzheimer’s disease
dc.subjectHesperidin
dc.subjectHuntington’s disease
dc.subjectNeuroprotective mechanisms
dc.subjectParkinson’s disease
dc.subjectantioxidant
dc.subjectflavonoid
dc.subjecthesperidin
dc.subjectneuroprotective agent
dc.subjectanimal
dc.subjectapoptosis
dc.subjectdegenerative disease
dc.subjectdrug effect
dc.subjecthuman
dc.subjectneuroprotection
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectApoptosis
dc.subjectFlavonoids
dc.subjectHesperidin
dc.subjectHumans
dc.subjectNeurodegenerative Diseases
dc.subjectNeuroprotection
dc.subjectNeuroprotective Agents
dc.titleHesperidin as a neuroprotective agent: A review of animal and clinical evidence
dc.typeReview


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