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Menopause status is associated with circadian- and sleep-related alterations
dc.contributor.author | Gómez-Santos C. | |
dc.contributor.author | Saura C.B. | |
dc.contributor.author | Lucas J.A.R. | |
dc.contributor.author | Castell P. | |
dc.contributor.author | Madrid J.A. | |
dc.contributor.author | Garaulet M. | |
dc.date.accessioned | 2020-09-02T22:19:58Z | |
dc.date.available | 2020-09-02T22:19:58Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1097/GME.0000000000000612 | |
dc.identifier.citation | 23, 6, 682-690 | |
dc.identifier.issn | 10723714 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/4830 | |
dc.description | Objective: The aim of the study was to investigate whether postmenopausal women show differences in circadian-related variables and sleep characteristics compared with premenopausal women, and to analyze potential associations between these circadian-related variables and abdominal fat distribution or metabolic syndrome (MetS) components. Methods: A total of 177 women were studied (127 premenopausal, 50 postmenopausal). Sixty percent of the total population was overweight/obese, with no significant differences between premenopausal (60%) and postmenopausal women (62%) (P = 0.865). Wrist temperature (WT) and rest-activity cycles were measured during 8 consecutive days, and sleep and food diaries collected. MetS characteristics and daily patterns of saliva cortisol were analyzed. Sleep characteristics were assessed with domiciliary polysomnography. Results: Postmenopausal women showed a less robust rhythm in WT with lower amplitude (°C) (0.8 ± 0.4 vs 0.9 ± 0.5) (P < 0.05) and lower mean temperature values at the midpoint of sleep than premenopausal women. Postmenopausal women were also more morning-type than premenopausal women, showing a phase advance of approximately 1 hour in WT and rest-activity rhythms, and more morning-type habits (earlier sleep onset/offset and breakfast intake) (P < 0.05). Postmenopausal women showed higher levels of activity in the morning and lower in the evening compared with premenopausal women (P < 0.05). Daily variability in cortisol was significantly reduced in postmenopausal women compared with premenopausal women (P < 0.05). Postmenopausal women had increased frequency of sleep-related breathing abnormalities (P < 0.0001). In the women studied, abdominal fat and MetS were associated with an increase in circadian alterations (high fragmentation and low amplitude of the rhythm) (P < 0.05). Conclusions: Postmenopausal women exhibit loss of circadian robustness and an increase in sleep abnormalities compared with premenopausal women. © 2016 by The North American Menopause Society. | |
dc.language.iso | en | |
dc.publisher | Lippincott Williams and Wilkins | |
dc.subject | Circadian | |
dc.subject | Cortisol | |
dc.subject | Menopause | |
dc.subject | Obesity | |
dc.subject | Polysomnography | |
dc.subject | Temperature | |
dc.subject | hydrocortisone | |
dc.subject | hydrocortisone | |
dc.subject | abdominal fat | |
dc.subject | abdominal obesity | |
dc.subject | adult | |
dc.subject | Article | |
dc.subject | circadian rhythm | |
dc.subject | circadian rhythm sleep disorder | |
dc.subject | controlled study | |
dc.subject | disease association | |
dc.subject | female | |
dc.subject | human | |
dc.subject | major clinical study | |
dc.subject | metabolic syndrome X | |
dc.subject | oxygen saturation | |
dc.subject | physical parameters | |
dc.subject | polysomnography | |
dc.subject | postmenopause | |
dc.subject | respiratory disturbance index | |
dc.subject | rest activity cycle | |
dc.subject | sleep quality | |
dc.subject | temperature | |
dc.subject | wrist temperature | |
dc.subject | abdominal obesity | |
dc.subject | analysis | |
dc.subject | body composition | |
dc.subject | chemistry | |
dc.subject | circadian rhythm | |
dc.subject | diet | |
dc.subject | glucose blood level | |
dc.subject | metabolic syndrome X | |
dc.subject | middle aged | |
dc.subject | obesity | |
dc.subject | pathophysiology | |
dc.subject | physiology | |
dc.subject | postmenopause | |
dc.subject | premenopause | |
dc.subject | saliva | |
dc.subject | sleep | |
dc.subject | sleep disorder | |
dc.subject | Spain | |
dc.subject | Abdominal Fat | |
dc.subject | Adult | |
dc.subject | Blood Glucose | |
dc.subject | Body Composition | |
dc.subject | Circadian Rhythm | |
dc.subject | Diet | |
dc.subject | Female | |
dc.subject | Humans | |
dc.subject | Hydrocortisone | |
dc.subject | Metabolic Syndrome | |
dc.subject | Middle Aged | |
dc.subject | Obesity | |
dc.subject | Obesity, Abdominal | |
dc.subject | Overweight | |
dc.subject | Postmenopause | |
dc.subject | Premenopause | |
dc.subject | Saliva | |
dc.subject | Sleep | |
dc.subject | Sleep Wake Disorders | |
dc.subject | Spain | |
dc.title | Menopause status is associated with circadian- and sleep-related alterations | |
dc.type | Article |