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Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)

dc.contributor.authorGómez R.M.
dc.contributor.authorSánchez M.Y.
dc.contributor.authorPortela-Lomba M.
dc.contributor.authorGhotme K.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSierra J.
dc.contributor.authorMoreno-Flores M.T.
dc.date.accessioned2020-09-02T22:19:55Z
dc.date.available2020-09-02T22:19:55Z
dc.date.issued2018
dc.identifier10.1002/glia.23282
dc.identifier.citation66, 7, 1267-1301
dc.identifier.issn08941491
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4807
dc.descriptionThe prospects of achieving regeneration in the central nervous system (CNS) have changed, as most recent findings indicate that several species, including humans, can produce neurons in adulthood. Studies targeting this property may be considered as potential therapeutic strategies to respond to injury or the effects of demyelinating diseases in the CNS. While CNS trauma may interrupt the axonal tracts that connect neurons with their targets, some neurons remain alive, as seen in optic nerve and spinal cord (SC) injuries (SCIs). The devastating consequences of SCIs are due to the immediate and significant disruption of the ascending and descending spinal pathways, which result in varying degrees of motor and sensory impairment. Recent therapeutic studies for SCI have focused on cell transplantation in animal models, using cells capable of inducing axon regeneration like Schwann cells (SchCs), astrocytes, genetically modified fibroblasts and olfactory ensheathing glia cells (OECs). Nevertheless, and despite the improvements in such cell-based therapeutic strategies, there is still little information regarding the mechanisms underlying the success of transplantation and regarding any secondary effects. Therefore, further studies are needed to clarify these issues. In this review, we highlight the properties of OECs that make them suitable to achieve neuroplasticity/neuroregeneration in SCI. OECs can interact with the glial scar, stimulate angiogenesis, axon outgrowth and remyelination, improving functional outcomes following lesion. Furthermore, we present evidence of the utility of cell therapy with OECs to treat SCI, both from animal models and clinical studies performed on SCI patients, providing promising results for future treatments. © 2018 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.subjectcell therapies
dc.subjectcell transplantation
dc.subjectneuroregeneration
dc.subjectolfactory ensheathing glia cells
dc.subjectspinal cord injuries
dc.subjecttransplantation
dc.subjectastrocyte
dc.subjectcell function
dc.subjectcell interaction
dc.subjectcell regeneration
dc.subjectcell therapy
dc.subjectcell transplantation
dc.subjectcentral nervous system
dc.subjectfibroblast
dc.subjecthuman
dc.subjectmyelination
dc.subjectnonhuman
dc.subjectolfactory ensheathing cell
dc.subjectolfactory mucosa
dc.subjectolfactory system
dc.subjectontogeny
dc.subjectpriority journal
dc.subjectReview
dc.subjectscar
dc.subjectSchwann cell
dc.subjectspinal cord injury
dc.subjectanimal
dc.subjectcell transplantation
dc.subjectcytology
dc.subjectglia
dc.subjectolfactory bulb
dc.subjectspinal cord injury
dc.subjecttransplantation
dc.subjectAnimals
dc.subjectCell Transplantation
dc.subjectHumans
dc.subjectNeuroglia
dc.subjectOlfactory Bulb
dc.subjectOlfactory Mucosa
dc.subjectSpinal Cord Injuries
dc.titleCell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)
dc.typeReview


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