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Ultrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats

dc.contributor.authorGómez R.M.
dc.contributor.authorGhotme K.
dc.contributor.authorBotero L.
dc.contributor.authorBernal J.E.
dc.contributor.authorPérez R.
dc.contributor.authorBarreto G.E.
dc.contributor.authorBustos R.H.
dc.date.accessioned2020-09-02T22:19:54Z
dc.date.available2020-09-02T22:19:54Z
dc.date.issued2016
dc.identifier10.1016/j.neures.2015.07.012
dc.identifier.citation103, , 10-17
dc.identifier.issn01680102
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4806
dc.descriptionOlfactory nerve derived and olfactory bulb derived olfactory ensheathing cells (OECs) have the ability to promote axonal regeneration and remyelination, both of which are essential in a successful cell transplant. Thus, morphological identification of OECs is a key aspect to develop an applicable cell therapy for injuries to the nervous system. However, there is no clear definition regarding which developmental stage or anatomical origin of OECs is more adequate for neural repair. In the present study, an ultrastructural comparison was made between OECs recovered from primary cultures of olfactory nerve and bulb in two developmental stages. The most notorious difference between cells obtained from olfactory nerve and bulb was the presence of indented nuclei in bulb derived OECs, suggesting a greater ability for possible chemotaxis. In neonatal OECs abundant mitochondria, lipid vacuoles, and smooth endoplasmic reticulum were detected, suggesting an active lipid metabolism, probably involved in synthesis of myelin. Our results suggest that neonatal OECs obtained from olfactory bulb have microscopic properties that could make them more suitable for neural repair. © 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society.
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectCell therapy
dc.subjectElectron microscopy
dc.subjectNeural repair
dc.subjectOlfactory ensheathing cells
dc.subjectRegeneration
dc.subjectmyelin
dc.subjectanimal cell
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectcell ultrastructure
dc.subjectcell vacuole
dc.subjectchemotaxis
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdevelopmental stage
dc.subjectjuvenile animal
dc.subjectlipid metabolism
dc.subjectmitochondrion
dc.subjectnerve cell culture
dc.subjectnewborn
dc.subjectnonhuman
dc.subjectolfactory bulb
dc.subjectolfactory ensheathing cell
dc.subjectolfactory nerve
dc.subjectphagolysosome
dc.subjectprimary culture
dc.subjectpriority journal
dc.subjectprotein synthesis
dc.subjectrat
dc.subjectsmooth endoplasmic reticulum
dc.subjectanimal
dc.subjectcell culture
dc.subjectglia
dc.subjectolfactory bulb
dc.subjectolfactory nerve
dc.subjectprimary cell culture
dc.subjectultrastructure
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectAnimals, Newborn
dc.subjectCells, Cultured
dc.subjectNeuroglia
dc.subjectOlfactory Bulb
dc.subjectOlfactory Nerve
dc.subjectPrimary Cell Culture
dc.subjectRats, Wistar
dc.titleUltrastructural analysis of olfactory ensheathing cells derived from olfactory bulb and nerve of neonatal and juvenile rats
dc.typeArticle


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