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Cotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice

dc.contributor.authorGrizzell J.A.
dc.contributor.authorPatel S.
dc.contributor.authorBarreto G.E.
dc.contributor.authorEcheverria V.
dc.date.accessioned2020-09-02T22:19:29Z
dc.date.available2020-09-02T22:19:29Z
dc.date.issued2017
dc.identifier10.1016/j.pnpbp.2017.05.010
dc.identifier.citation78, , 75-81
dc.identifier.issn02785846
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4754
dc.descriptionAlzheimer's disease (AD) is associated with the progressive aggregation of hyperphosphorylated forms of the microtubule associated protein Tau in the central nervous system. Cotinine, the main metabolite of nicotine, reduced working memory deficits, synaptic loss, and amyloid β peptide aggregation into oligomers and plaques as well as inhibited the cerebral Tau kinase, glycogen synthase 3β (GSK3β) in the transgenic (Tg)6799 (5XFAD) mice. In this study, the effect of cotinine on visual recognition memory and cortical Tau phosphorylation at the GSK3β sites Serine (Ser)-396/Ser-404 and phospho-CREB were investigated in the Tg6799 and non-transgenic (NT) littermate mice. Tg mice showed short-term visual recognition memory impairment in the novel object recognition test, and higher levels of Tau phosphorylation when compared to NT mice. Cotinine significantly improved visual recognition memory performance increased CREB phosphorylation and reduced cortical Tau phosphorylation. Potential mechanisms underlying theses beneficial effects are discussed. © 2017
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectAlzheimer's disease
dc.subjectCotinine
dc.subjectCREB
dc.subjectMemory
dc.subjectTau
dc.subjectcotinine
dc.subjectcyclic AMP responsive element binding protein
dc.subjectphosphoprotein
dc.subjectserine
dc.subjecttau protein
dc.subjectcotinine
dc.subjectCreb1 protein, mouse
dc.subjectcyclic AMP responsive element binding protein
dc.subjecttau protein
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbinding site
dc.subjectbrain cortex
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjectdrug mechanism
dc.subjectmale
dc.subjectmemory disorder
dc.subjectmouse
dc.subjectnonhuman
dc.subjectnovel object recognition test
dc.subjectprotein phosphorylation
dc.subjectvisual memory
dc.subjectvisual recognition memory
dc.subjectanimal
dc.subjectdrug effects
dc.subjectmemory
dc.subjectmetabolism
dc.subjectphosphorylation
dc.subjectrecognition
dc.subjecttransgenic mouse
dc.subjectvision
dc.subjectAnimals
dc.subjectCerebral Cortex
dc.subjectCotinine
dc.subjectCyclic AMP Response Element-Binding Protein
dc.subjectMale
dc.subjectMemory
dc.subjectMice
dc.subjectMice, Transgenic
dc.subjectPhosphorylation
dc.subjectRecognition (Psychology)
dc.subjecttau Proteins
dc.subjectVisual Perception
dc.titleCotinine improves visual recognition memory and decreases cortical Tau phosphorylation in the Tg6799 mice
dc.typeArticle


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