Mostrar el registro sencillo del ítem

Cotinine reduces depressive-like behavior and hippocampal vascular endothelial growth factor downregulation after forced swim stress in mice

dc.contributor.authorGrizzell J.A.
dc.contributor.authorMullins M.
dc.contributor.authorIarkov A.
dc.contributor.authorRohani A.
dc.contributor.authorCharry L.C.
dc.contributor.authorEcheverria V.
dc.date.accessioned2020-09-02T22:19:28Z
dc.date.available2020-09-02T22:19:28Z
dc.date.issued2014
dc.identifier10.1037/bne0000021
dc.identifier.citation128, 6, 713-721
dc.identifier.issn07357044
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4753
dc.descriptionCotinine, the predominant metabolite of nicotine, appears to act as an antidepressant. We have previously shown that cotinine reduced immobile postures in Porsolt's forced swim (FS) and tail suspension tests while preserving the synaptic density in the hippocampus as well as prefrontal and entorhinal cortices of mice subjected to chronic restraint stress. In this study, we investigated the effect of daily oral cotinine (5 mg/kg) on depressive-like behavior induced by repeated, FS stress for 6 consecutive days in adult, male C57BL/6J mice. The results support our previous report that cotinine administration reduces depressive-like behavior in mice subjected or not to high salience stress. In addition, cotinine enhanced the expression of the vascular endothelial growth factor (VEGF) in the hippocampus of mice subjected to repetitive FS stress. Altogether, the results suggest that cotinine may be an effective antidepressant positively influencing mood through a mechanism involving the preservation of brain homeostasis and the expression of critical growth factors such as VEGF.
dc.language.isoen
dc.publisherAmerican Psychological Association Inc.
dc.subjectDepressive disorders
dc.subjectForced swim
dc.subjectNeurogenesis
dc.subjectVascular endothelial growth factor
dc.subjectcotinine
dc.subjectvasculotropin
dc.subjectantidepressant agent
dc.subjectbungarotoxin receptor
dc.subjectcotinine
dc.subjectcyclic AMP responsive element binding protein binding protein
dc.subjectDlgh4 protein, mouse
dc.subjectguanylate kinase
dc.subjectmembrane protein
dc.subjectmessenger RNA
dc.subjecttubulin
dc.subjectvasculotropin A
dc.subjectadult
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantidepressant activity
dc.subjectArticle
dc.subjectbrain metabolism
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectdown regulation
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectforced swim test
dc.subjecthippocampus
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprotein analysis
dc.subjectprotein expression
dc.subjectanimal
dc.subjectC57BL mouse
dc.subjectcomplication
dc.subjectdepression
dc.subjectdisease model
dc.subjectdrug effects
dc.subjectgenetics
dc.subjectmental stress
dc.subjectmetabolism
dc.subjectpsychology
dc.subjectswimming
dc.subjecttime
dc.subjectalpha7 Nicotinic Acetylcholine Receptor
dc.subjectAnimals
dc.subjectAntidepressive Agents
dc.subjectCotinine
dc.subjectCREB-Binding Protein
dc.subjectDepression
dc.subjectDisease Models, Animal
dc.subjectDown-Regulation
dc.subjectGuanylate Kinase
dc.subjectHippocampus
dc.subjectMale
dc.subjectMembrane Proteins
dc.subjectMice
dc.subjectMice, Inbred C57BL
dc.subjectRNA, Messenger
dc.subjectStress, Psychological
dc.subjectSwimming
dc.subjectTime Factors
dc.subjectTubulin
dc.subjectVascular Endothelial Growth Factor A
dc.titleCotinine reduces depressive-like behavior and hippocampal vascular endothelial growth factor downregulation after forced swim stress in mice
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84925798534.pdf
Tamaño:
3.892Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem