Mostrar el registro sencillo del ítem

Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice

dc.contributor.authorGrizzell J.A.
dc.contributor.authorIarkov A.
dc.contributor.authorHolmes R.
dc.contributor.authorMori T.
dc.contributor.authorEcheverria V.
dc.date.accessioned2020-09-02T22:19:28Z
dc.date.available2020-09-02T22:19:28Z
dc.date.issued2014
dc.identifier10.1016/j.bbr.2014.03.047
dc.identifier.citation268, , 55-65
dc.identifier.issn01664328
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4752
dc.descriptionChronic stress underlies and/or exacerbates many psychiatric conditions and often results in memory impairment as well as depressive symptoms. Such afflicted individuals use tobacco more than the general population and this has been suggested as a form of self-medication. Cotinine, the predominant metabolite of nicotine, may underlie such behavior as it has been shown to ameliorate anxiety and memory loss in animal models. In this study, we sought to investigate the effects of cotinine on working memory and depressive-like behavior in mice subjected to prolonged restraint. Cotinine-treated mice displayed better performance than vehicle-treated cohorts on the working memory task, the radial arm water maze test. In addition, with or without chronic stress exposure, cotinine-treated mice engaged in fewer depressive-like behaviors as assessed using the tail suspension and Porsolt's forced swim tests. These antidepressant and nootropic effects of cotinine were associated with an increase in the synaptophysin expression, a commonly used marker of synaptic density, in the hippocampus as well as the prefrontal and entorhinal cortices of restrained mice. The beneficial effects of cotinine in preventing various consequences of chronic stress were underscored by the inhibition of the glycogen synthase kinase 3 β in the hippocampus and prefrontal cortex. Taken together, our results show for the first time that cotinine reduces the negative effects of stress on mood, memory, and the synapse. © 2014.
dc.language.isoen
dc.publisherElsevier
dc.subjectCotinine
dc.subjectDepression
dc.subjectMemory
dc.subjectRestraint
dc.subjectStress
dc.subjectSynaptophysin
dc.subjectantidepressant agent
dc.subjectcotinine
dc.subjectglycogen synthase kinase 3
dc.subjectglycogen synthase kinase 3 beta
dc.subjectnootropic agent
dc.subjectsynaptophysin
dc.subjectSyp protein, mouse
dc.subjectanimal
dc.subjectbrain
dc.subjectC57BL mouse
dc.subjectchronic disease
dc.subjectdepression
dc.subjectdisease model
dc.subjectdrug effects
dc.subjectdrug therapy
dc.subjectexercise
dc.subjectmale
dc.subjectMemory Disorders
dc.subjectmental stress
dc.subjectmetabolism
dc.subjectmotor activity
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectshort term memory
dc.subjectsynapse
dc.subjectAnimals
dc.subjectAntidepressive Agents
dc.subjectBrain
dc.subjectChronic Disease
dc.subjectCotinine
dc.subjectDepression
dc.subjectDisease Models, Animal
dc.subjectGlycogen Synthase Kinase 3
dc.subjectMale
dc.subjectMemory Disorders
dc.subjectMemory, Short-Term
dc.subjectMice, Inbred C57BL
dc.subjectMotor Activity
dc.subjectNootropic Agents
dc.subjectRestraint, Physical
dc.subjectStress, Psychological
dc.subjectSynapses
dc.subjectSynaptophysin
dc.titleCotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice
dc.typeArticle


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84898884197.pdf
Tamaño:
3.537Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem