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Gliomas: New perspectives in diagnosis, treatment and prognosis

dc.contributor.authorGhotme K.A.
dc.contributor.authorBarreto G.E.
dc.contributor.authorEcheverria V.
dc.contributor.authorGonzalez J.
dc.contributor.authorBustos R.H.
dc.contributor.authorSanchez M.
dc.contributor.authorLeszek J.
dc.contributor.authorYarla N.S.
dc.contributor.authorGomez R.M.
dc.contributor.authorTarasov V.V.
dc.contributor.authorMd Ashraf G.
dc.contributor.authorAliev G.
dc.date.accessioned2020-09-02T22:19:27Z
dc.date.available2020-09-02T22:19:27Z
dc.date.issued2017
dc.identifier10.2174/1568026617666170103162639
dc.identifier.citation17, 12, 1438-1447
dc.identifier.issn15680266
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4748
dc.descriptionGliomas are central nervous system tumors originated from glial cells, whose incidence and mortality is expected to rise in coming years, especially in developing countries. Diagnosis and classification of gliomas have largely relied on tumor histopathologic features that provide limited information regarding response to therapy or prognosis. Current treatment of gliomas is surgery combined with chemotherapy and/or radiotherapy. However, many tumors show a high resistance to these interventions, and recurrences are frequent since conventional therapies do not take into account the unique molecular features of different subtypes of glioma. Molecular genetics provide new insights in classifying gliomas and predicting response to therapy that can range from conventional treatments to new revolutionary therapeutic approaches. This article offers a review of the intracellular signaling pathways involved in carcinogenesis of gliomas, as well as a description of new tools for their diagnosis, prognosis, and treatment with a target-oriented approach. © 2017 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectBiomarkers
dc.subjectGenotype
dc.subjectGlioma
dc.subjectGliomagenesis
dc.subjectPhenotype
dc.subjectPrognosis
dc.subjectSignaling pathways
dc.subjectTreatment
dc.subjectcancer chemotherapy
dc.subjectcancer incidence
dc.subjectcarcinogenesis
dc.subjectgene amplification
dc.subjectgene expression
dc.subjectgene repression
dc.subjectgenetic analysis
dc.subjectglioma
dc.subjecthuman
dc.subjectintracellular signaling
dc.subjectmortality rate
dc.subjectReview
dc.subjectsensitivity analysis
dc.subjectsignal transduction
dc.subjecttranscription initiation
dc.subjecttumor growth
dc.subjecttumor invasion
dc.subjectCentral Nervous System Neoplasms
dc.subjectdrug effects
dc.subjectgenetics
dc.subjectglioma
dc.subjectantineoplastic agent
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectCentral Nervous System Neoplasms
dc.subjectGlioma
dc.subjectHumans
dc.subjectSignal Transduction
dc.titleGliomas: New perspectives in diagnosis, treatment and prognosis
dc.typeReview


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