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The Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases

dc.contributor.authorGorabi A.M.
dc.contributor.authorKiaie N.
dc.contributor.authorBarreto G.E.
dc.contributor.authorRead M.I.
dc.contributor.authorTafti H.A.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:19:25Z
dc.date.available2020-09-02T22:19:25Z
dc.date.issued2019
dc.identifier10.1007/s12035-019-01663-0
dc.identifier.citation56, 12, 8157-8167
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4732
dc.descriptionNeurologic complications are commonly regarded as irreversible impairments that stem from limited potential of regeneration of the central nervous system (CNS). On the other side, the regenerative potential of stem cells has been evaluated in basic research, as well as in preclinical studies. Mesenchymal stem cells (MSCs) have been regarded as candidate cell sources for therapeutic purposes of various neurological disorders, because of their self-renewal ability, plasticity in differentiation, neurotrophic characteristics, and immunomodulatory properties. Exosomes are extracellular vesicles which can deliver biological information over long distances and thereby influencing normal and abnormal processes in cells and tissues. The therapeutic capacity of exosomes relies on the type of cell, as well as on the physiological condition of a given cell. Therefore, based on tissue type and physiological condition of CNS, exosomes may function as contributors or suppressors of pathological conditions in this tissue. When it comes to the therapeutic viewpoint, the most promising cellular source of exosomes is considered to be MSCs. The aim of this review article is to discuss the current knowledge around the potential of stem cells and MSC-derived exosomes in the treatment of neurodegenerative diseases. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectCentral nervous system
dc.subjectExosome
dc.subjectNeurodegenerative diseases
dc.subjectNeuroprotection
dc.subjectRegeneration
dc.subjectStem cell
dc.subjectbiogenesis
dc.subjectblood brain barrier
dc.subjectcell interaction
dc.subjectcell manipulation
dc.subjectcell regeneration
dc.subjectdegenerative disease
dc.subjectexosome
dc.subjecthuman
dc.subjectmesenchymal stem cell
dc.subjectmesenchymal stem cell transplantation
dc.subjectnerve cell
dc.subjectnervous system inflammation
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectReview
dc.subjectsignal transduction
dc.subjectanimal
dc.subjectdegenerative disease
dc.subjectexosome
dc.subjectmesenchymal stem cell
dc.subjectmesenchymal stem cell transplantation
dc.subjectphysiology
dc.subjectprocedures
dc.subjecttransplantation
dc.subjectAnimals
dc.subjectExosomes
dc.subjectHumans
dc.subjectMesenchymal Stem Cell Transplantation
dc.subjectMesenchymal Stem Cells
dc.subjectNeurodegenerative Diseases
dc.titleThe Therapeutic Potential of Mesenchymal Stem Cell–Derived Exosomes in Treatment of Neurodegenerative Diseases
dc.typeReview


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