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Effects of Curcumin on Microglial Cells

dc.contributor.authorGhasemi F.
dc.contributor.authorBagheri H.
dc.contributor.authorBarreto G.E.
dc.contributor.authorRead M.I.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:19:23Z
dc.date.available2020-09-02T22:19:23Z
dc.date.issued2019
dc.identifier10.1007/s12640-019-00030-0
dc.identifier.citation36, 1, 12-26
dc.identifier.issn10298428
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4726
dc.descriptionMicroglia are innate immune system cells which reside in the central nervous system (CNS). Resting microglia regulate the homeostasis of the CNS via phagocytic activity to clear pathogens and cell debris. Sometimes, however, to protect neurons and fight invading pathogens, resting microglia transform to an activated-form, producing inflammatory mediators, such as cytokines, chemokines, iNOS/NO and cyclooxygenase-2 (COX-2). Excessive inflammation, however, leads to damaged neurons and neurodegenerative diseases (NDs), such as Parkinson’s disease (PD), Alzheimer’s disease (AD), Huntington’s disease (HD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Curcumin is a phytochemical isolated from Curcuma longa. It is widely used in Asia and has many therapeutic properties, including antioxidant, anti-viral, anti-bacterial, anti-mutagenic, anti-amyloidogenic and anti-inflammatory, especially with respect to neuroinflammation and neurological disorders (NDs). Curcumin is a pleiotropic molecule that inhibits microglia transformation, inflammatory mediators and subsequent NDs. In this mini-review, we discuss the effects of curcumin on microglia and explore the underlying mechanisms. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
dc.language.isoen
dc.publisherSpringer New York LLC
dc.subjectCurcumin
dc.subjectMicroglia, neuroinflammation
dc.subjectNeurodegenerative diseases
dc.subjectNeuroprotection
dc.subjectcurcumin
dc.subjectperoxisome proliferator activated receptor gamma
dc.subjectSTAT3 protein
dc.subjecttranscription factor Nrf2
dc.subjectantiinflammatory agent
dc.subjectcurcumin
dc.subjectantineoplastic activity
dc.subjectcell activation
dc.subjectcell function
dc.subjectcell protection
dc.subjectcentral nervous system
dc.subjectclinical trial (topic)
dc.subjectdegenerative disease
dc.subjectdisease association
dc.subjectdrug effect
dc.subjectdrug mechanism
dc.subjectglioblastoma
dc.subjecthuman
dc.subjectimmunocompetent cell
dc.subjectin vitro study
dc.subjectin vivo study
dc.subjectmicroglia
dc.subjectmolecularly targeted therapy
dc.subjectnervous system inflammation
dc.subjectnonhuman
dc.subjectParkinson disease
dc.subjectPersian Gulf syndrome
dc.subjectpriority journal
dc.subjectReview
dc.subjectsignal transduction
dc.subjectanimal
dc.subjectbrain
dc.subjectencephalitis
dc.subjectimmunology
dc.subjectmicroglia
dc.subjectnerve cell
dc.subjectAnimals
dc.subjectAnti-Inflammatory Agents
dc.subjectBrain
dc.subjectCurcumin
dc.subjectEncephalitis
dc.subjectHumans
dc.subjectMicroglia
dc.subjectNeurons
dc.titleEffects of Curcumin on Microglial Cells
dc.typeReview


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