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Tibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid

dc.contributor.authorGonzález-Giraldo Y.
dc.contributor.authorGarcia-Segura L.M.
dc.contributor.authorEcheverria V.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:19:23Z
dc.date.available2020-09-02T22:19:23Z
dc.date.issued2018
dc.identifier10.1007/s12035-017-0667-3
dc.identifier.citation55, 5, 4453-4462
dc.identifier.issn08937648
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4723
dc.descriptionObesity has been associated with increased chronic neuroinflammation and augmented risk of neurodegeneration. This is worsened during the normal aging process when the levels of endogenous gonadal hormones are reduced. In this study, we have assessed the protective actions of tibolone, a synthetic steroid with estrogenic actions, on T98G human astrocytic cells exposed to palmitic acid, a saturated fatty acid used to mimic obesity in vitro. Tibolone improved cell survival, and preserved mitochondrial membrane potential in palmitic acid-treated astrocytic cells. Although we did not find significant actions of tibolone on free radical production, it modulated astrocytic morphology after treatment with palmitic acid. These data suggest that tibolone protects astrocytic cells by preserving both mitochondrial functionality and morphological complexity. © 2017, Springer Science+Business Media, LLC.
dc.language.isoen
dc.publisherHumana Press Inc.
dc.subjectAstrocytes
dc.subjectMitochondria
dc.subjectMorphology
dc.subjectPalmitic acid
dc.subjectTibolone
dc.subjectpalmitic acid
dc.subjectreactive oxygen metabolite
dc.subjecttibolone
dc.subjectpalmitic acid
dc.subjectpregnane derivative
dc.subjecttibolone
dc.subjectArticle
dc.subjectastrocyte
dc.subjectcell damage
dc.subjectcell function
dc.subjectcell structure
dc.subjectcell survival
dc.subjectcell viability
dc.subjectcontrolled study
dc.subjectdrug effect
dc.subjecthuman
dc.subjecthuman cell
dc.subjectin vitro study
dc.subjectmitochondrial membrane potential
dc.subjectmitochondrion
dc.subjectMTT assay
dc.subjectneuroprotection
dc.subjectobesity
dc.subjectT98G cell line
dc.subjectastrocyte
dc.subjectcell shape
dc.subjectcytology
dc.subjectmetabolism
dc.subjectmitochondrion
dc.subjecttumor cell line
dc.subjectAstrocytes
dc.subjectCell Line, Tumor
dc.subjectCell Shape
dc.subjectCell Survival
dc.subjectHumans
dc.subjectMitochondria
dc.subjectNorpregnenes
dc.subjectPalmitic Acid
dc.titleTibolone Preserves Mitochondrial Functionality and Cell Morphology in Astrocytic Cells Treated with Palmitic Acid
dc.typeArticle


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