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The adverse prognostic effect of tumor budding on the evolution of cutaneous head and neck squamous cell carcinoma

dc.contributor.authorGonzalez-Guerrero M.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorVivanco B.
dc.contributor.authorFernández-Vega I.
dc.contributor.authorMunguía-Calzada P.
dc.contributor.authorGonzalez-Gutierrez M.P.
dc.contributor.authorRodrigo J.P.
dc.contributor.authorGalache C.
dc.contributor.authorSantos-Juanes J.
dc.date.accessioned2020-09-02T22:19:21Z
dc.date.available2020-09-02T22:19:21Z
dc.date.issued2017
dc.identifier10.1016/j.jaad.2017.01.015
dc.identifier.citation76, 6, 1139-1145
dc.identifier.issn01909622
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4712
dc.descriptionBackground Tumor budding is a readily detectable histopathologic feature that has been recognized as an adverse prognostic factor in several human cancers. Objective We sought to assess the correlation of tumor budding with the clinicopathologic features and the prognostic value of tumor budding in cutaneous squamous cell carcinoma (cSCC). Methods Forty-nine primary nonmetastatic and 49 primary metastatic cSCCs to regional lymph nodes were retrospectively studied. Statistical analyses were carried out to assess the relationship between tumor budding, clinicopathologic parameters, and patient survival. Results Tumor budding was observed in 45 cases of 98 (46%). High-intensity budding (≥5 tumor buds) was observed in 20 tumors. Presence of tumor buds was a significant risk factor for nodal metastasis with crude and adjusted hazard ratios (HRs) of 8.92 (95% CI, 4.39-18.1) and 6.93 (95% CI, 3.30-14.5), respectively, and for reduced overall survival time (crude and adjusted HRs of 2.03 [95% CI, 1.26-3.28] and 1.72 [95% CI, 1.05-2.83], respectively). Limitations This was a retrospective study limited to cSCCs of the head and neck. Examined tumors were >2 mm thick, and all were from a primary excision. Conclusion These results indicate an increased frequency of nodal metastasis and risk of death in patients with tumor buds. © 2017 American Academy of Dermatology, Inc.
dc.language.isoen
dc.publisherMosby Inc.
dc.subjecthead and neck
dc.subjectmetastasis
dc.subjectsquamous cell carcinoma
dc.subjectaged
dc.subjectArticle
dc.subjectcancer risk
dc.subjectcancer survival
dc.subjectcell budding
dc.subjectclinical article
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectfemale
dc.subjectfollow up
dc.subjecthead and neck squamous cell carcinoma
dc.subjecthuman
dc.subjectmale
dc.subjectoverall survival
dc.subjectpriority journal
dc.subjectprognostic assessment
dc.subjectretrospective study
dc.subjectskin carcinoma
dc.subjecttumor budding
dc.subjecttumor differentiation
dc.subjecthead and neck tumor
dc.subjectlymph node metastasis
dc.subjectmiddle aged
dc.subjectmortality
dc.subjectpathology
dc.subjectprognosis
dc.subjectsquamous cell carcinoma
dc.subjectsurvival rate
dc.subjecttumor invasion
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCarcinoma, Squamous Cell
dc.subjectFemale
dc.subjectHead and Neck Neoplasms
dc.subjectHumans
dc.subjectLymphatic Metastasis
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Invasiveness
dc.subjectPrognosis
dc.subjectRetrospective Studies
dc.subjectSurvival Rate
dc.titleThe adverse prognostic effect of tumor budding on the evolution of cutaneous head and neck squamous cell carcinoma
dc.typeArticle


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