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Combined strategy for a reliable evaluation of spinal cord injury using an in vivo model

dc.contributor.authorGomez R.M.
dc.contributor.authorGhotme K.
dc.contributor.authorNiño J.J.
dc.contributor.authorQuiroz-Padilla M.
dc.contributor.authorVargas D.
dc.contributor.authorDomínguez A.R.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSanchez M.Y.
dc.date.accessioned2020-09-02T22:19:19Z
dc.date.available2020-09-02T22:19:19Z
dc.date.issued2018
dc.identifier10.2174/1871524915666150819104114
dc.identifier.citation18, 1, 49-57
dc.identifier.issn18715249
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4698
dc.descriptionBackground: A complete neurological exam contributes in establishing spinal cord injury severity and its extent by identifying the damage to the sensory and motor pathways involved in order to address a more case-specific and precise pharmacological therapy. However, assessment of neurologic function in spinal cord injury models is usually reported by using sensory or motor tests independently.? Methods: A reliable integral method is needed to precisely evaluate location and severity of the injury at baseline and, in further assessments, to establish the degree of spontaneous recovery. A combination of sensation-based tests and motor-based tests was used to evaluate impaired neurologic function after spinal cord injury and the degree of spontaneous recovery, in different stages, on an in vivo model.? Results: Combined neurologic evaluation was useful to establish location and severity of the injury in all animals and also to detect degrees of spontaneous recovery at different stages after the injury. Comparisons of neurological function were assessed in time-days and groups between BBB motor score, latency maintenance of posture, locomotion and latency presentation of grooming before and after the injury. Our results suggest that a combined assessment strategy, including sensory and motor tests, can lead to better evaluation of spinal cord injury severity and location, and documentation of the extent of spontaneous recovery following SCI and identify specific motor and sensory pathway integrity.? Conclusion: In conclusion, a combined assessment strategy provides a concise method for evaluating the impact of interventions in experimental models of SCI. © 2018 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectEvaluation and locomotion
dc.subjectMotor test
dc.subjectSensory and motor pathways
dc.subjectSensory test
dc.subjectSpecific CNS therapy
dc.subjectSpinal Cord Injury (SCI)
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectArticle
dc.subjectbehavior assessment
dc.subjectbiomechanics
dc.subjectdermatome
dc.subjectexperimental locomotor activity test
dc.subjectgrooming
dc.subjectlocomotion
dc.subjectmale
dc.subjectmusculoskeletal system parameters
dc.subjectnonhuman
dc.subjectparaplegia
dc.subjectrat
dc.subjectsensorimotor function
dc.subjectsensory evaluation
dc.subjectspinal cord injury
dc.subjectwalk test
dc.subjectwithdrawal reflex
dc.subjectanimal
dc.subjectconvalescence
dc.subjectdisease model
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectphysiology
dc.subjectrandomization
dc.subjectreaction time
dc.subjectspinal cord injury
dc.subjectthoracic vertebra
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectDisease Models, Animal
dc.subjectLocomotion
dc.subjectMale
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReaction Time
dc.subjectRecovery of Function
dc.subjectSpinal Cord Injuries
dc.subjectThoracic Vertebrae
dc.titleCombined strategy for a reliable evaluation of spinal cord injury using an in vivo model
dc.typeArticle


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