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Novel Approaches in Astrocyte Protection: from Experimental Methods to Computational Approaches

dc.contributor.authorGarzón D.
dc.contributor.authorCabezas R.
dc.contributor.authorVega N.
dc.contributor.authorÁvila-Rodriguez M.
dc.contributor.authorGonzalez J.
dc.contributor.authorGómez R.M.
dc.contributor.authorEcheverria V.
dc.contributor.authorAliev G.
dc.contributor.authorBarreto G.E.
dc.date.accessioned2020-09-02T22:18:56Z
dc.date.available2020-09-02T22:18:56Z
dc.date.issued2016
dc.identifier10.1007/s12031-016-0719-6
dc.identifier.citation58, 4, 483-492
dc.identifier.issn08958696
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4666
dc.descriptionAstrocytes are important for normal brain functioning. Astrocytes are metabolic regulators of the brain that exert many functions such as the preservation of blood–brain barrier (BBB) function, clearance of toxic substances, and generation of antioxidant molecules and growth factors. These functions are fundamental to sustain the function and survival of neurons and other brain cells. For these reasons, the protection of astrocytes has become relevant for the prevention of neuronal death during brain pathologies such as Parkinson’s disease, Alzheimer’s disease, stroke, and other neurodegenerative conditions. Currently, different strategies are being used to protect the main astrocytic functions during neurological diseases, including the use of growth factors, steroid derivatives, mesenchymal stem cell paracrine factors, nicotine derivatives, and computational biology tools. Moreover, the combined use of experimental approaches with bioinformatics tools such as the ones obtained through system biology has allowed a broader knowledge in astrocytic protection both in normal and pathological conditions. In the present review, we highlight some of these recent paradigms in assessing astrocyte protection using experimental and computational approaches and discuss how they could be used for the study of restorative therapies for the brain in pathological conditions. © 2016, Springer Science+Business Media New York.
dc.language.isoen
dc.publisherSpringer New York LLC
dc.subjectAstrocytes
dc.subjectComputational biology
dc.subjectGrowth factors
dc.subjectMesenchymal stem factors
dc.subjectNeurosteroids
dc.subjectNicotine
dc.subjectestrogen
dc.subjectestrogen derivative
dc.subjectglial cell line derived neurotrophic factor
dc.subjectnicotine
dc.subjectplatelet derived growth factor
dc.subjectneuroprotective agent
dc.subjectastrocyte
dc.subjectbioinformatics
dc.subjectbiology
dc.subjectcell protection
dc.subjectdegenerative disease
dc.subjecthuman
dc.subjectmesenchymal stem cell
dc.subjectneuroprotection
dc.subjectneuroscience
dc.subjectnonhuman
dc.subjectReview
dc.subjectanimal
dc.subjectastrocyte
dc.subjectbiology
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectmolecularly targeted therapy
dc.subjectNeurodegenerative Diseases
dc.subjectprocedures
dc.subjectAnimals
dc.subjectAstrocytes
dc.subjectComputational Biology
dc.subjectHumans
dc.subjectMolecular Targeted Therapy
dc.subjectNeurodegenerative Diseases
dc.subjectNeuroprotective Agents
dc.titleNovel Approaches in Astrocyte Protection: from Experimental Methods to Computational Approaches
dc.typeReview


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