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Elevated Systemic Inflammatory Burden and Cardiovascular Risk in Young Adults with Endodontic Apical Lesions

dc.contributor.authorGarrido M.
dc.contributor.authorCárdenas A.M.
dc.contributor.authorAstorga J.
dc.contributor.authorQuinlan F.
dc.contributor.authorValdés M.
dc.contributor.authorChaparro A.
dc.contributor.authorCarvajal P.
dc.contributor.authorPussinen P.
dc.contributor.authorHuamán-Chipana P.
dc.contributor.authorJalil J.E.
dc.contributor.authorHernández M.
dc.date.accessioned2020-09-02T22:18:54Z
dc.date.available2020-09-02T22:18:54Z
dc.date.issued2019
dc.identifier10.1016/j.joen.2018.11.014
dc.identifier.citation45, 2, 111-115
dc.identifier.issn00992399
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4657
dc.descriptionIntroduction: The aim of this study was to assess whether apical lesions are associated with inflammatory serum markers of cardiovascular risk, especially high-sensitivity C-reactive protein (hsCRP), in young adults. Methods: In this cross-sectional study, otherwise healthy individuals with apical lesions of endodontic origin (ALEOs) and a clinical diagnosis of asymptomatic apical periodontitis and controls aged between 18 and 40 years were included. Patients’ sociodemographic characteristics, medical history, and classic cardiovascular risk factors were recorded, and the pathobiological determinants of atherosclerosis in youth score was calculated. Oral clinical and radiographic examinations were performed. Blood samples were collected to determine the lipid profile, glycated hemoglobin, hsCRP, immunoglobulin G, interleukin (IL)-6, IL-10, IL-12p70, matrix metalloproteinase 8, soluble vascular cellular adhesion molecule-1, soluble intercellular adhesion molecule-1, and soluble E-selectin. Bivariate and multivariate analyses adjusting for oral and classic cardiovascular risk factors were performed. Results: hsCRP levels were significantly higher in ALEO patients versus controls (median = 2.54 vs 0.78), whereas the pathobiological determinants of atherosclerosis in youth score was comparable among the groups. Also, the levels of IL-6, matrix metalloproteinase 8, and soluble E-selectin were significantly higher in ALEO patients. hsCRP, IL-6, and IL-12 correlated with soluble adhesion molecules. Bivariate analysis based on hsCRP serum concentrations ≥1 mg/L showed an odds ratio (OR) = 6.8, and the risk increased 3.3 times for an additional ALEO. In multivariate analysis, ALEO was significantly associated with hsCRP levels ≥1 mg/L (OR = 5.1–12.8) independently of the adjustment model. ALEO also associated with CRP levels >3 mg/L, which was significant after the adjustment for covariates (OR = 4.0). Conclusions: ALEO is associated with the systemic inflammatory burden and cardiovascular risk determined by hsCRP, supporting a mechanistic link for cardiovascular diseases in young adults. © 2018 American Association of Endodontists
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectC-reactive protein
dc.subjectCardiovascular diseases
dc.subjectE-selectin
dc.subjectinterleukin 6
dc.subjectperiapical periodontitis
dc.subjectbiological marker
dc.subjectC reactive protein
dc.subjectendothelial leukocyte adhesion molecule 1
dc.subjectinterleukin 6
dc.subjectadolescent
dc.subjectadult
dc.subjectblood
dc.subjectcardiovascular disease
dc.subjectcomplication
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjecthuman
dc.subjectmale
dc.subjectrisk factor
dc.subjectsystemic inflammatory response syndrome
dc.subjecttooth periapical disease
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectBiomarkers
dc.subjectC-Reactive Protein
dc.subjectCardiovascular Diseases
dc.subjectCross-Sectional Studies
dc.subjectE-Selectin
dc.subjectFemale
dc.subjectHumans
dc.subjectInterleukin-6
dc.subjectMale
dc.subjectPeriapical Periodontitis
dc.subjectRisk Factors
dc.subjectSystemic Inflammatory Response Syndrome
dc.subjectYoung Adult
dc.titleElevated Systemic Inflammatory Burden and Cardiovascular Risk in Young Adults with Endodontic Apical Lesions
dc.typeArticle


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