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Endoneurial-CD34 positive cells define an intermediate layer in human digital Pacinian corpuscles

dc.contributor.authorGarcía-Piqueras J.
dc.contributor.authorGarcía-Suárez O.
dc.contributor.authorRodríguez-González M.C.
dc.contributor.authorCobo J.L.
dc.contributor.authorCabo R.
dc.contributor.authorVega J.A.
dc.contributor.authorFeito J.
dc.date.accessioned2020-09-02T22:18:52Z
dc.date.available2020-09-02T22:18:52Z
dc.date.issued2017
dc.identifier10.1016/j.aanat.2017.01.006
dc.identifier.citation211, , 55-60
dc.identifier.issn09409602
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4646
dc.descriptionThe endoneurial and/or perineurial origin of the outer core; i.e. the concentric and continuous lamellae located outside the complex formed by the axon and the Schwann-related cells, in human Pacinian corpuscles is still debated. Here we used immunohistochemistry coupled with a battery of antibodies to investigate the expression of perineurial (Glucose transporter 1 and epithelial membrane antigen) or endoneurial (CD34 antigen) markers in human digital Pacinian corpuscles. CD34 immunoreactivity was restricted to one layer immediately outside the inner core, whereas the proper outer core displayed antigens typical of the perineurial cells. These results demonstrate an intermediate endoneurial layer that divides the Pacinian corpuscles into two distinct compartments: the avascular inner neural compartment (formed by the axon and the Schwann-related cells that form the inner core), and the outer non-neural compartment (formed by the outer core). The functional relevance of these findings, if any, remains to be clarified. © 2017 Elsevier GmbH
dc.language.isoen
dc.publisherElsevier GmbH
dc.subjectCD34 antigen
dc.subjectEndoneurium
dc.subjectHuman
dc.subjectImmunohistochemistry
dc.subjectPacinian corpuscles
dc.subjectCD34 antigen
dc.subjectepithelial membrane antigen
dc.subjectglucose transporter 1
dc.subjectCD34 antigen
dc.subjectglucose transporter 1
dc.subjectmucin 1
dc.subjectadolescent
dc.subjectadult
dc.subjectaged
dc.subjectantigen expression
dc.subjectArticle
dc.subjectaxon
dc.subjectcell compartmentalization
dc.subjectchild
dc.subjectendoneurium
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectPacini corpuscle
dc.subjectperineurium
dc.subjectSchwann cell
dc.subjectanatomy and histology
dc.subjectcadaver
dc.subjectcytology
dc.subjectfemale
dc.subjectfinger
dc.subjectinnervation
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectPacini corpuscle
dc.subjectperipheral nerve
dc.subjecttissue distribution
dc.subjectultrastructure
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAntigens, CD34
dc.subjectCadaver
dc.subjectFemale
dc.subjectFingers
dc.subjectGlucose Transporter Type 1
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMucin-1
dc.subjectPacinian Corpuscles
dc.subjectPeripheral Nerves
dc.subjectTissue Distribution
dc.subjectYoung Adult
dc.titleEndoneurial-CD34 positive cells define an intermediate layer in human digital Pacinian corpuscles
dc.typeArticle


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