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Class I and Class II small leucine-rich proteoglycans in human cutaneous pacinian corpuscles
dc.contributor.author | García-Piqueras J. | |
dc.contributor.author | García-Mesa Y. | |
dc.contributor.author | Feito J. | |
dc.contributor.author | García B. | |
dc.contributor.author | Quiros L.M. | |
dc.contributor.author | Martín-Biedma B. | |
dc.contributor.author | Cobo T. | |
dc.contributor.author | Vega J.A. | |
dc.contributor.author | García-Suárez O. | |
dc.date.accessioned | 2020-09-02T22:18:52Z | |
dc.date.available | 2020-09-02T22:18:52Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1016/j.aanat.2019.02.007 | |
dc.identifier.citation | 224, , 62-72 | |
dc.identifier.issn | 09409602 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/4644 | |
dc.description | Pacinian corpuscles are onion bulb-like multilayered mechanoreceptors that consist of a complicated structure of axon terminals, Schwann related cells (inner core), endoneural related cells (intermediate layer) and perineurial related cells (outer core-capsule). The cells forming those compartments are continuous and share the properties of that covering the nerve fibers. Small leucine-rich proteoglycans are major proteoglycans of the extracellular matrix and regulate collagen fibrillogenesis, cell signalling pathways and extracellular matrix assembly. Here we used immunohistochemistry to investigate the distribution of class I (biglycan, decorin, asporin, ECM2 and ECMX) and class II (fibromodulin, lumican, prolargin, keratocan and osteoadherin) small leucine-rich proteoglycans in human cutaneous Pacinian corpuscles. The distribution of these compounds was: the inner core express decorin, biglycan, lumican, fibromodulin, osteoadherin; the intermediate layer display immunoreactivity for osteoadherin; the outer core biglycan, decorin, lumican, fibromodulin and osteoadherin; and the capsule contains biglycan, decorin, fibromodulin, and lumican. Asporin, prolargin and keratocan were undetectable. These results complement our knowledge about the distribution of small leucine-rich proteoglycans in human Pacinian corpuscles, and help to understand the composition of the extracellular matrix in these sensory formations. © 2019 Elsevier GmbH | |
dc.language.iso | en | |
dc.publisher | Elsevier GmbH | |
dc.subject | Extracellular matrix | |
dc.subject | Human | |
dc.subject | Pacinian corpuscles | |
dc.subject | Small leucine-rich proteoglycans | |
dc.subject | asporin | |
dc.subject | biglycan | |
dc.subject | decorin | |
dc.subject | fibromodulin | |
dc.subject | keratocan | |
dc.subject | lumican | |
dc.subject | osteoadherin | |
dc.subject | prolargin | |
dc.subject | small leucine rich proteoglycan | |
dc.subject | small leucine rich proteoglycan class I | |
dc.subject | small leucine rich proteoglycan class II | |
dc.subject | unclassified drug | |
dc.subject | biglycan | |
dc.subject | CD34 antigen | |
dc.subject | decorin | |
dc.subject | fibromodulin | |
dc.subject | osteoadherin | |
dc.subject | protein S 100 | |
dc.subject | proteoglycan | |
dc.subject | scleroprotein | |
dc.subject | vimentin | |
dc.subject | adolescent | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | Article | |
dc.subject | child | |
dc.subject | controlled study | |
dc.subject | extracellular matrix | |
dc.subject | human | |
dc.subject | human experiment | |
dc.subject | human tissue | |
dc.subject | immunohistochemistry | |
dc.subject | immunoreactivity | |
dc.subject | normal human | |
dc.subject | Pacini corpuscle | |
dc.subject | protein analysis | |
dc.subject | protein expression | |
dc.subject | protein localization | |
dc.subject | signal transduction | |
dc.subject | anatomy and histology | |
dc.subject | animal | |
dc.subject | chemistry | |
dc.subject | classification | |
dc.subject | Equidae | |
dc.subject | finger | |
dc.subject | fluorescent antibody technique | |
dc.subject | goat | |
dc.subject | Leporidae | |
dc.subject | middle aged | |
dc.subject | mouse | |
dc.subject | Pacini corpuscle | |
dc.subject | skin | |
dc.subject | young adult | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Animals | |
dc.subject | Antigens, CD34 | |
dc.subject | Biglycan | |
dc.subject | Child | |
dc.subject | Decorin | |
dc.subject | Equidae | |
dc.subject | Extracellular Matrix Proteins | |
dc.subject | Fibromodulin | |
dc.subject | Fingers | |
dc.subject | Fluorescent Antibody Technique | |
dc.subject | Goats | |
dc.subject | Humans | |
dc.subject | Immunohistochemistry | |
dc.subject | Mice | |
dc.subject | Middle Aged | |
dc.subject | Pacinian Corpuscles | |
dc.subject | Proteoglycans | |
dc.subject | Rabbits | |
dc.subject | S100 Proteins | |
dc.subject | Skin | |
dc.subject | Vimentin | |
dc.subject | Young Adult | |
dc.title | Class I and Class II small leucine-rich proteoglycans in human cutaneous pacinian corpuscles | |
dc.type | Article |