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The capsule of human Meissner corpuscles: immunohistochemical evidence

dc.contributor.authorGarcía-Piqueras J.
dc.contributor.authorCobo R.
dc.contributor.authorCárcaba L.
dc.contributor.authorGarcía-Mesa Y.
dc.contributor.authorFeito J.
dc.contributor.authorCobo J.
dc.contributor.authorGarcía-Suárez O.
dc.contributor.authorVega J.A.
dc.date.accessioned2020-09-02T22:18:51Z
dc.date.available2020-09-02T22:18:51Z
dc.date.issued2020
dc.identifier10.1111/joa.13139
dc.identifier.citation236, 5, 854-861
dc.identifier.issn00218782
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4642
dc.descriptionMeissner corpuscles are cutaneous mechanoreceptors that are usually located in the dermal papillae of human glabrous skin. Structurally, these sensory corpuscles consist of a mechanoreceptive sensory neuron surrounded by non-myelinating lamellar Schwann-like cells. Some authors have described a partially developed fibroblastic capsule of endoneurial or perineurial origin around Meissner corpuscles; however, others have noted that these structures are non-encapsulated. As there is continuity between the periaxonic cells forming the sensory corpuscles and the cells of the nerve trunks, we used immunohistochemistry to examine the expression of endoneurial (CD34 antigen) or perineurial [Glucose transporter 1 (Glut1)] markers in human cutaneous Meissner corpuscles. We also investigated the immunohistochemical patterns of nestin and vimentin (the main intermediate filaments of the cytoskeleton of endoneurial and perineurial cells, respectively) in Meissner corpuscles. The most important finding from this study was that CD34-positive cells formed a partial/complete capsule of endoneurial origin around most Meissner corpuscles, without signs of other perineurial Glut1-positive elements. However, the cytoskeletal proteins of the capsular CD34-positive cells did not include either nestin or vimentin, so the cytoskeletal composition of these cells remains to be established. Finally, the intensity of the immunoreactivity for CD34 in the capsule decreased with ageing, sometimes becoming completely absent in the oldest individuals. In conclusion, we report the first immunohistochemical evidence of the capsule of Meissner corpuscles in humans and demonstrate the endoneurial origin of the capsule. © 2019 Anatomical Society
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectcapsule
dc.subjectCD34 antigen
dc.subjectendoneurium
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectMeissner corpuscles
dc.subjectCD34 antigen
dc.subjectcytoskeleton protein
dc.subjectglucose transporter 1
dc.subjectnestin
dc.subjectvimentin
dc.subjectadult
dc.subjectaged
dc.subjectantigen expression
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcytoskeleton
dc.subjectendoneurial cell
dc.subjectendoneurium
dc.subjectglabrous skin
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmechanoreceptor
dc.subjectMeissner corpuscle
dc.subjectperineurial cell
dc.subjectperineurium
dc.subjectpriority journal
dc.subjectSchwann cell
dc.subjectsensory nerve cell
dc.subjectvery elderly
dc.titleThe capsule of human Meissner corpuscles: immunohistochemical evidence
dc.typeArticle


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