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Chondroitin Sulfate in Human Cutaneous Meissner and Pacinian Sensory Corpuscles

dc.contributor.authorGarcía-Piqueras J.
dc.contributor.authorCarcaba L.
dc.contributor.authorGarcía-Mesa Y.
dc.contributor.authorFeito J.
dc.contributor.authorGarcía B.
dc.contributor.authorViña E.
dc.contributor.authorSuárez-Quintanilla J.
dc.contributor.authorCobo J.
dc.contributor.authorVega J.A.
dc.contributor.authorGarcía-Suárez O.
dc.date.accessioned2020-09-02T22:18:51Z
dc.date.available2020-09-02T22:18:51Z
dc.date.issued2019
dc.identifier10.1002/ar.23951
dc.identifier.citation302, 2, 325-331
dc.identifier.issn19328486
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4641
dc.descriptionChondroitin sulfate is a glycosaminoglycan involved in maintaining the morphofunctional properties of the extracellular matrix in peripheral nerves, but its distribution in human sensory corpuscles is unknown despite the role of extracellular matrix in mechanotransduction and axonal guidance. In this study we used immunohistochemistry to analyze the distribution of chondroitin sulfate in human cutaneous Meissner and Pacinian corpuscles. Chondroitin sulfate expression was absent from Meissner corpuscles. In Pacinian corpuscles chondroitin sulfate was found associated to a CD34 positive endoneurial-related layer, interposed between the S100 protein positive inner core cells, and the vimentin positive inner core and outer core-capsule cells. Therefore, the intermediate CD34+/chondroitin sulfate+ intermediate layer present in Pacinian corpuscles isolates the neural segment of the corpuscles (axon and inner core) from the non-neural segments (outer core and capsule). These results suggest a role of chondroitin sulfate in the proper axonal growth and guidance, within the neuronal compartment of the Pacinian corpuscles during development and reinnervation, can be hypothesized. Moreover, a role of CS in mechanotransduction cannot be ruled out. Anat Rec, 302:325–331, 2019. © 2018 Wiley Periodicals, Inc. © 2018 Wiley Periodicals, Inc.
dc.language.isoen
dc.publisherBlackwell Publishing Inc.
dc.subjectchondroitin sulfate
dc.subjectextracellular matrix
dc.subjecthuman
dc.subjectintermediate layer
dc.subjectMeissner corpuscles
dc.subjectPacinian corpuscles
dc.subjectCD34 antigen
dc.subjectchondroitin sulfate
dc.subjectprotein S 100
dc.subjectvimentin
dc.subjectchondroitin sulfate
dc.subjectadult
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectcutaneous meissner
dc.subjectenzymatic degradation
dc.subjectextracellular matrix
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectimmunoreactivity
dc.subjectmechanoreceptor
dc.subjectmechanotransduction
dc.subjectneuromere
dc.subjectPacini corpuscle
dc.subjectperipheral nerve
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectreinnervation
dc.subjectskin surface
dc.subjectadolescent
dc.subjectchild
dc.subjectmechanoreceptor
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectPacini corpuscle
dc.subjectsensory ganglion
dc.subjectskin
dc.subjectyoung adult
dc.subjectAdolescent
dc.subjectAdult
dc.subjectChild
dc.subjectChondroitin Sulfates
dc.subjectGanglia, Sensory
dc.subjectHumans
dc.subjectMechanoreceptors
dc.subjectMechanotransduction, Cellular
dc.subjectMiddle Aged
dc.subjectPacinian Corpuscles
dc.subjectPeripheral Nerves
dc.subjectSkin
dc.subjectYoung Adult
dc.titleChondroitin Sulfate in Human Cutaneous Meissner and Pacinian Sensory Corpuscles
dc.typeArticle


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