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Tumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck

dc.contributor.authorGarcía-Pedrero J.M.
dc.contributor.authorMartínez-Camblor P.
dc.contributor.authorDiaz-Coto S.
dc.contributor.authorMunguia-Calzada P.
dc.contributor.authorVallina-Alvarez A.
dc.contributor.authorVazquez-Lopez F.
dc.contributor.authorRodrigo J.P.
dc.contributor.authorSantos-Juanes J.
dc.date.accessioned2020-09-02T22:18:51Z
dc.date.available2020-09-02T22:18:51Z
dc.date.issued2017
dc.identifier10.1016/j.jaad.2017.05.047
dc.identifier.citation77, 3, 527-533
dc.identifier.issn01909622
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4639
dc.descriptionBackground Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 expression has been associated with poor outcome in a wide variety of cancers; however, data in cutaneous squamous cell carcinoma (cSCC) are scarce and conflicting. Objective To investigate the relationship of tumor PD-L1 expression with the clinicopathologic features and prognosis of cSCC. Methods PD-L1 expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 100 patients with cSCC. Cumulative/dynamic receiver operating characteristic curve was used to determine the optimal PD-L1 threshold. Kaplan-Meier estimators and Cox proportional hazards regression models were also used. Results On the basis of cumulative/dynamic receiver operating characteristic curves, we defined the cut-off score for PD-L1 expression as ≥25% of tumor cells positively stained. PD-L1 expression was a significant risk factor for nodal metastasis with crude and adjusted hazard ratios of 3.39 (1.71-6.65) and 6.54 (2.28-18.78), respectively. Limitations This is a retrospective study limited to cSCC of the head and neck. Conclusion These findings indicate that tumor PD-L1 expression predicts increased risk for nodal metastasis in patients with cSCC. © 2017 American Academy of Dermatology, Inc.
dc.language.isoen
dc.publisherMosby Inc.
dc.subjectcutaneous squamous cell carcinoma
dc.subjectexpression
dc.subjectimmunohistochemistry
dc.subjectnodal metastasis
dc.subjectPD-L1
dc.subjectprognosis
dc.subjecttumor
dc.subjectprogrammed death 1 ligand 1
dc.subjectprogrammed death 1 ligand 1
dc.subjectaged
dc.subjectArticle
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectcancer staging
dc.subjectcancer survival
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfollow up
dc.subjecthead and neck carcinoma
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectimmunohistochemistry
dc.subjectlymph node metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectoverall survival
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectskin carcinoma
dc.subjectT lymphocyte activation
dc.subjecttissue microarray
dc.subjecttumor differentiation
dc.subjecttumor growth
dc.subjecttumor volume
dc.subjectwide excision
dc.subjectbiosynthesis
dc.subjecthead and neck tumor
dc.subjectlymph node metastasis
dc.subjectmetabolism
dc.subjectpathology
dc.subjectsecondary
dc.subjectskin tumor
dc.subjectsquamous cell carcinoma
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAntigens, CD274
dc.subjectCarcinoma, Squamous Cell
dc.subjectFemale
dc.subjectHead and Neck Neoplasms
dc.subjectHumans
dc.subjectLymphatic Metastasis
dc.subjectMale
dc.subjectRetrospective Studies
dc.subjectSkin Neoplasms
dc.titleTumor programmed cell death ligand 1 expression correlates with nodal metastasis in patients with cutaneous squamous cell carcinoma of the head and neck
dc.typeArticle


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