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Can physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis

dc.contributor.authorGarcía-Hermoso A.
dc.contributor.authorRamírez-Vélez R.
dc.contributor.authorCelis-Morales C.A.
dc.contributor.authorOlloquequi J.
dc.contributor.authorIzquierdo M.
dc.date.accessioned2020-09-02T22:18:49Z
dc.date.available2020-09-02T22:18:49Z
dc.date.issued2018
dc.identifier10.1016/j.exger.2018.03.002
dc.identifier.citation106, , 173-177
dc.identifier.issn05315565
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4633
dc.descriptionThe purpose of this study was to examine the combined association of sitting time and physical activity with cognitive function and to determine whether moderate-to-vigorous physical activity (MVPA) is a mediator of the association between sitting time and cognitive function in a nationally representative sample of older adults from Chile. Data from 989 older adults (≥65 years old, 61.3% female) from the 2009–2010 Chilean Health Survey were analyzed. Physical activity and sitting time were measured using the Global Physical Activity questionnaire. Cognitive function was assessed using the modified Mini-Mental State levels Examination. Physical activity levels were categorized as “inactive” (<600 metabolic equivalent value minutes per week) or “active” (≥600 metabolic equivalent value minutes per week). Sitting time was categorized as “sedentary”, defined as ≥4 h of reported sitting time per day, or “non-sedentary”, defined as <4 h. We created the following groups (i) non-sedentary/active; (ii) non-sedentary/inactive; (iii) sedentary/active; and (iv) sedentary/inactive. Hayes's PROCESS macro was used for the simple mediation analysis. Compared with the reference group (individuals classified as non-sedentary/active), older adults who were classified as sedentary/active had elevated odds of cognitive impairment (OR = 1.90, [95% CI, 1.84 to 3.85]). However, the odds ratio for cognitive impairment was substantially increased in those classified as sedentary/inactive (OR = 4.85 [95% CI, 2.54 to 6.24]) compared with the reference group. MVPA was found to mediate the relationship between sitting time and cognitive function (Indirect Effect = −0.070 [95% CI, −0.012 to −0.004]). Conclusion: The present findings suggest that, whether overall physical activity is high or low, spending large amounts of time sitting is associated with elevated odds of cognitive impairment and that MVPA slightly weakens the relationship between sitting time and cognitive function. © 2018 Elsevier Inc.
dc.language.isoen
dc.publisherElsevier Inc.
dc.subjectAging
dc.subjectCognitive impairment
dc.subjectPhysical inactivity
dc.subjectSedentary behavior
dc.subjectaged
dc.subjectalcohol consumption
dc.subjectArticle
dc.subjectattention
dc.subjectbody mass
dc.subjectcognitive defect
dc.subjectComposite International Diagnostic Interview
dc.subjectcontrolled study
dc.subjectdepression
dc.subjectdepression assessment
dc.subjectdisease association
dc.subjectDSM-IV
dc.subjectfemale
dc.subjecthuman
dc.subjectlanguage
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmemory
dc.subjectmetabolic equivalent
dc.subjectMini Mental State Examination
dc.subjectorientation
dc.subjectphysical activity
dc.subjectprevalence
dc.subjectpriority journal
dc.subjectsitting
dc.subjecttobacco use
dc.subjectaging
dc.subjectChile
dc.subjectcognition
dc.subjectcognitive defect
dc.subjectcross-sectional study
dc.subjectexercise
dc.subjecthealth survey
dc.subjectpsychological rating scale
dc.subjectpsychology
dc.subjectstatistical model
dc.subjectvery elderly
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAging
dc.subjectChile
dc.subjectCognition
dc.subjectCognitive Dysfunction
dc.subjectCross-Sectional Studies
dc.subjectExercise
dc.subjectFemale
dc.subjectHealth Surveys
dc.subjectHumans
dc.subjectLogistic Models
dc.subjectMale
dc.subjectPsychiatric Status Rating Scales
dc.subjectSedentary Behavior
dc.titleCan physical activity attenuate the negative association between sitting time and cognitive function among older adults? A mediation analysis
dc.typeArticle


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