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Moderate-to-vigorous physical activity as a mediator between sedentary behavior and cardiometabolic risk in Spanish healthy adults: A mediation analysis

dc.contributor.authorGarcía-Hermoso A.
dc.contributor.authorMartínez-Vizcaíno V.
dc.contributor.authorSánchez-López M.
dc.contributor.authorRecio-Rodriguez J.I.
dc.contributor.authorGómez-Marcos M.A.
dc.contributor.authorGarcía-Ortiz L.
dc.contributor.authorand for the EVIDENT Group
dc.date.accessioned2020-09-02T22:18:49Z
dc.date.available2020-09-02T22:18:49Z
dc.date.issued2015
dc.identifier10.1186/s12966-015-0244-y
dc.identifier.citation12, 1, -
dc.identifier.issn14795868
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4632
dc.descriptionBackground: Public health strategies for cardiovascular prevention highlight the importance of physical activity, but do not consider the additional potentially harmful effects of sedentary behavior. This study was conducted between 2010 and 2012 and analyzed between 2013 and 2014. The aim of the study was to analyze the relationship between sedentary behavior and cardiometabolic risk factors in the Spanish adult population and to examine whether this relationship is mediated by moderate-to-vigorous physical activity (MVPA). Methods: The cross-sectional study included 1122 healthy subjects belonging to the EVIDENT study. Sedentary behavior was objectively measured over 7 days using Actigraph accelerometers. We assessed waist circumference (WC), triglycerides-to-HDL-C ratio (TG/HDL-C), and mean arterial pressure (MAP), and undertook homeostasis model assessment (HOMA-IR). Linear regression models were fitted according to Baron and Kenny procedures for mediation analysis. Results: TG/HDL-C and HOMA-IR were significantly higher in adults who spent more minutes in sedentary activities after adjusting for potential covariates. However when MVPA was added to the ANCOVA models as covariate the effect of sedentary time on HOMA-IR disappeared. In addition, MVPA acted as a full mediator of the relationship between sedentary time and HOMA-IR. In contrast, subjects with lower levels of MVPA presented worse cardiometabolic profiles than those from higher MVPA categories, even after controlling for sedentary time and other potential confounders. Conclusions: These results suggest that both MVPA and sedentary time should be considered when developing cardiometabolic risk guidelines. Trial registration: NCT01083082. © 2015 García-Hermoso et al.
dc.language.isoen
dc.publisherBioMed Central Ltd.
dc.subjectInsulin resistance
dc.subjectMediation analysis
dc.subjectModerate-to-vigorous physical activity
dc.subjectSedentary lifestyle
dc.subjectglucose
dc.subjecthigh density lipoprotein cholesterol
dc.subjectinsulin
dc.subjecttriacylglycerol
dc.subjectHDL-triglyceride
dc.subjecthigh density lipoprotein
dc.subjecthigh density lipoprotein cholesterol
dc.subjecttriacylglycerol
dc.subjectactimetry
dc.subjectadult
dc.subjectaged
dc.subjectalcohol consumption
dc.subjectArticle
dc.subjectblood pressure measurement
dc.subjectbody mass
dc.subjectcardiometabolic risk
dc.subjectcross-sectional study
dc.subjectfemale
dc.subjecthomeostasis model assessment of insulin resistance
dc.subjecthuman
dc.subjectinsulin resistance
dc.subjectlinear regression analysis
dc.subjectmale
dc.subjectmean arterial pressure
dc.subjectmedical assessment
dc.subjectmoderate to vigorous physical activity
dc.subjectphysical activity
dc.subjectsedentary lifestyle
dc.subjectsmoking
dc.subjectSpaniard
dc.subjectvery elderly
dc.subjectwaist circumference
dc.subjectblood pressure
dc.subjectCardiovascular Diseases
dc.subjectexercise
dc.subjectmetabolic syndrome X
dc.subjectmiddle aged
dc.subjectphysiology
dc.subjectrisk factor
dc.subjectSpain
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBlood Pressure
dc.subjectCardiovascular Diseases
dc.subjectCholesterol, HDL
dc.subjectCross-Sectional Studies
dc.subjectExercise
dc.subjectFemale
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectLipoproteins, HDL
dc.subjectMale
dc.subjectMetabolic Syndrome X
dc.subjectMiddle Aged
dc.subjectRisk Factors
dc.subjectSedentary Lifestyle
dc.subjectSpain
dc.subjectTriglycerides
dc.subjectWaist Circumference
dc.subjectYoung Adult
dc.titleModerate-to-vigorous physical activity as a mediator between sedentary behavior and cardiometabolic risk in Spanish healthy adults: A mediation analysis
dc.typeArticle


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