Mostrar el registro sencillo del ítem

Vitamin C in the treatment and/or prevention of obesity

dc.contributor.authorGarcia-Diaz D.F.
dc.contributor.authorLopez-Legarrea P.
dc.contributor.authorQuintero P.
dc.contributor.authorMartinez J.A.
dc.date.accessioned2020-09-02T22:18:43Z
dc.date.available2020-09-02T22:18:43Z
dc.date.issued2014
dc.identifier10.3177/jnsv.60.367
dc.identifier.citation60, 6, 367-379
dc.identifier.issn03014800
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4592
dc.descriptionObesity has emerged as one of the major health threats worldwide. Moreover, an excessive body fat accumulation, which defines this disease, could lead to several associated clinical manifestations such as cardiovascular events, type 2 diabetes, inflammation, and some types of cancer. The appearance of these co-morbidities has been often related to an unbalanced oxidative stress. Therefore, antioxidant-based treatments could be considered as interesting approaches to possibly counteract obesity fat accumulation complications. In this context, it has been observed that vitamin C intake (ascorbic acid) is negatively associated with the occurrence of several conditions such as hypertension, gallbladder disease, stroke, cancers, and atherosclerosis, and also with the onset of obesity in humans and animals. Among the possible beneficial effects of ascorbic acid on obesity-related mechanisms, it has been suggested that this vitamin may: (a) modulate adipocyte lipolysis; (b) regulate the glucocorticoid release from adrenal glands; (c) inhibit glucose metabolism and leptin secretion on isolated adipocytes; (d) lead to an improvement in hyperglycemia and decrease glycosylation in obese-diabetic models; and (e) reduce the inflammatory response. Possibly, all these features could be related with the outstanding antioxidant characteristics of this vitamin. Thus, the present article reviews the up-to-date evidence regarding in vitro and in vivo effects of vitamin C in obesity and its co-morbidities. © 2014, Center for Academic Publications Japan. All Rights Reserved.
dc.language.isoen
dc.publisherCenter for Academic Publications Japan
dc.subjectAntioxidant
dc.subjectAscorbic acid
dc.subjectBody weight
dc.subjectOxidative stress
dc.subjectascorbic acid
dc.subjectglucocorticoid
dc.subjectleptin
dc.subjectantioxidant
dc.subjectascorbic acid
dc.subjectglucocorticoid
dc.subjectvitamin
dc.subjectatherosclerosis
dc.subjectcerebrovascular accident
dc.subjectgallbladder disease
dc.subjectglucose metabolism
dc.subjectglycosylation
dc.subjecthuman
dc.subjecthyperglycemia
dc.subjecthypertension
dc.subjecthypoxia
dc.subjectinflammation
dc.subjectlipid storage
dc.subjectlipolysis
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectobesity
dc.subjectoxidative stress
dc.subjectReview
dc.subjectvitamin intake
dc.subjectadipocyte
dc.subjectadrenal gland
dc.subjectanimal
dc.subjectdrug effects
dc.subjectmetabolism
dc.subjectobesity
dc.subjectAnimalia
dc.subjectAdipocytes
dc.subjectAdrenal Glands
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectAscorbic Acid
dc.subjectGlucocorticoids
dc.subjectHumans
dc.subjectObesity
dc.subjectOxidative Stress
dc.subjectVitamins
dc.titleVitamin C in the treatment and/or prevention of obesity
dc.typeReview


Ficheros en el ítem

Thumbnail
Nombre:
item_2-s2.0-84926395616.pdf
Tamaño:
3.491Kb
Formato:
PDF
Ver/

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem