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Interindividual variation in cardiorespiratory fitness: A candidate gene study in han Chinese people

dc.contributor.authorGaowa
dc.contributor.authorDel Coso J.
dc.contributor.authorGu Z.
dc.contributor.authorGerile W.
dc.contributor.authorYang R.
dc.contributor.authorDíaz-Peña R.
dc.contributor.authorValenzuela P.L.
dc.contributor.authorLucia A.
dc.contributor.authorHe Z.
dc.date.accessioned2020-09-02T22:18:43Z
dc.date.available2020-09-02T22:18:43Z
dc.date.issued2020
dc.identifier10.3390/genes11050555
dc.identifier.citation11, 5, -
dc.identifier.issn20734425
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4589
dc.descriptionCardiorespiratory fitness, as assessed through peak oxygen uptake (VO2peak), is a powerful health indicator. We aimed to evaluate the influence of several candidate causal genetic variants on VO2peak level in untrained Han Chinese people. A total of 1009 participants (566 women; age [mean ± SD] 40 ± 14 years, VO2peak 29.9 ± 7.1 mL/kg/min) performed a maximal incremental cycling test for VO2peak determination. Genomic DNA was extracted from peripheral whole blood, and genotyping analysis was performed on 125 gene variants. Using age, sex, and body mass as covariates, and setting a stringent threshold p-value of 0.0004, only one single nucleotide polymorphism (SNP), located in the gene encoding angiotensin-converting enzyme (rs4295), was associated with VO2peak (β = 0.87; p < 2.9 × 10−4). Stepwise multiple regression analysis identified a panel of three SNPs (rs4295 = 1.1%, angiotensin II receptor type 1 rs275652 = 0.6%, and myostatin rs7570532 = 0.5%) that together accounted for 2.2% (p = 0.0007) of the interindividual variance in VO2peak. Participants carrying six ‘favorable’ alleles had a higher VO2peak (32.3 ± 8.1 mL/kg/min) than those carrying only one favorable allele (24.6 ± 5.2 mL/kg/min, p < 0.0001). In summary, VO2peak at the pre-trained state is partly influenced by several polymorphic variations in candidate genes, but they represent a minor portion of the variance. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectEndurance performance
dc.subjectGenomics
dc.subjectMaximal oxygen uptake
dc.subjectSingle nucleotide polymorphism
dc.subjectVO2max
dc.subjectalpha actinin 3
dc.subjectalpha ketoglutarate dependent dioxygenase FTO
dc.subjectangiotensin 2 receptor
dc.subjectangiotensin converting enzyme 2
dc.subjectangiotensin receptor
dc.subjectangiotensinogen
dc.subjectbradykinin B2 receptor
dc.subjectdipeptidyl carboxypeptidase
dc.subjectfibroblast growth factor 21
dc.subjectfibroblast growth factor receptor 2
dc.subjectfollistatin
dc.subjectgenomic DNA
dc.subjectinterleukin 15
dc.subjectinterleukin 6
dc.subjectlong chain fatty acid coenzyme A ligase
dc.subjectmyostatin
dc.subjectpeptide YY
dc.subjectperoxisome proliferator activated receptor gamma coactivator 1alpha
dc.subjectrenin
dc.subjectresistin
dc.subjectadult
dc.subjectage
dc.subjectaged
dc.subjectallele
dc.subjectArticle
dc.subjectbody mass
dc.subjectcardiorespiratory fitness
dc.subjectcross-sectional study
dc.subjectcycling
dc.subjectDNA extraction
dc.subjectfemale
dc.subjectgenetic variation
dc.subjectgenotype
dc.subjectHan Chinese
dc.subjecthuman
dc.subjecthuman experiment
dc.subjectmale
dc.subjectnormal human
dc.subjectobservational study
dc.subjectoxygen consumption
dc.subjectsex difference
dc.subjectsingle nucleotide polymorphism
dc.subjectyoung adult
dc.titleInterindividual variation in cardiorespiratory fitness: A candidate gene study in han Chinese people
dc.typeArticle


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