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rs2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts

dc.contributor.authorFuku N.
dc.contributor.authorDíaz-Peña R.
dc.contributor.authorArai Y.
dc.contributor.authorAbe Y.
dc.contributor.authorPareja-Galeano H.
dc.contributor.authorSanchis-Gomar F.
dc.contributor.authorSantos-Lozano A.
dc.contributor.authorZempo H.
dc.contributor.authorNaito H.
dc.contributor.authorMurakami H.
dc.contributor.authorMiyachi M.
dc.contributor.authorVenturini L.
dc.contributor.authorRicevuti G.
dc.contributor.authorNobuyoshi H.
dc.contributor.authorEmanuele E.
dc.contributor.authorLucia A.
dc.date.accessioned2020-09-02T22:18:03Z
dc.date.available2020-09-02T22:18:03Z
dc.date.issued2016
dc.identifier10.1016/j.maturitas.2016.07.016
dc.identifier.citation92, , 110-114
dc.identifier.issn03785122
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4546
dc.descriptionObjectives Previous studies have indicated that the rs2802292 polymorphism in the human forkhead box O3A (FOXO3A) gene might be associated with exceptional longevity (EL, i.e., living 100+ years), although the results are conflicting. Study design and main outcome measures Using a case-control design, we investigated the distribution of the rs2802292 polymorphism in two ethnically distinct cohorts of centenarians (cases) and younger adults (controls). The first cohort included Japanese individuals (733 centenarians and 820 controls) and the second was from Northern Italy (79 disease-free centenarians and 316 controls). Results No statistically significant association was found between the rs2802292 polymorphism and EL in either cohort (either examined in their entirety or in a sex-based analysis). Conclusions In light of our negative findings, further research and resequencing efforts are needed to shed more light on the potential association between EL and FOXO3A polymorphisms. © 2016
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.subjectAging
dc.subjectCentenarian
dc.subjectFOXO3A
dc.subjectGenetics
dc.subjectLongevity
dc.subjectPolymorphism
dc.subjecttranscription factor FKHRL1
dc.subjectFOXO3 protein, human
dc.subjecttranscription factor FKHRL1
dc.subjectaged
dc.subjectaging
dc.subjectArticle
dc.subjectcohort analysis
dc.subjectcontrolled study
dc.subjectDNA polymorphism
dc.subjectethnicity
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgene sequence
dc.subjectgenetic association
dc.subjectgenotype
dc.subjecthuman
dc.subjectJapanese (people)
dc.subjectlongevity
dc.subjectmale
dc.subjectvery elderly
dc.subjectadult
dc.subjectcase control study
dc.subjectethnic group
dc.subjectgenetics
dc.subjectItaly
dc.subjectJapan
dc.subjectlongevity
dc.subjectmiddle aged
dc.subjectsingle nucleotide polymorphism
dc.subjectyoung adult
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectCase-Control Studies
dc.subjectCohort Studies
dc.subjectEthnic Groups
dc.subjectFemale
dc.subjectForkhead Box Protein O3
dc.subjectGenotype
dc.subjectHumans
dc.subjectItaly
dc.subjectJapan
dc.subjectLongevity
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPolymorphism, Single Nucleotide
dc.subjectYoung Adult
dc.titlers2802292 polymorphism in the FOXO3A gene and exceptional longevity in two ethnically distinct cohorts
dc.typeArticle


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