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Matrix metalloproteinases as regulators of periodontal inflammation

dc.contributor.authorFranco C.
dc.contributor.authorPatricia H.-R.
dc.contributor.authorTimo S.
dc.contributor.authorClaudia B.
dc.contributor.authorMarcela H.
dc.date.accessioned2020-09-02T22:17:59Z
dc.date.available2020-09-02T22:17:59Z
dc.date.issued2017
dc.identifier10.3390/ijms18020440
dc.identifier.citation18, 2, -
dc.identifier.issn16616596
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4522
dc.descriptionPeriodontitis are infectious diseases characterized by immune-mediated destruction of periodontal supporting tissues and tooth loss. Matrix metalloproteinases (MMPs) are key proteases involved in destructive periodontal diseases. The study and interest in MMP has been fuelled by emerging evidence demonstrating the broad spectrum of molecules that can be cleaved by them and the myriad of biological processes that they can potentially regulate. The huge complexity of MMP functions within the ‘protease web’ is crucial for many physiologic and pathologic processes, including immunity, inflammation, bone resorption, and wound healing. Evidence points out that MMPs assemble in activation cascades and besides their classical extracellular matrix substrates, they cleave several signalling molecules—such as cytokines, chemokines, and growth factors, among others—regulating their biological functions and/or bioavailability during periodontal diseases. In this review, we provide an overview of emerging evidence of MMPs as regulators of periodontal inflammation. © 2017 by the authors; licensee MDPI, Basel, Switzerland.
dc.language.isoen
dc.publisherMDPI AG
dc.subjectChronic periodontitis
dc.subjectMMPs
dc.subjectModulation
dc.subjectPeriodontal inflammation regulation
dc.subjectchemokine
dc.subjectcollagenase 3
dc.subjectCXCL1 chemokine
dc.subjectcytokine
dc.subjectgelatinase
dc.subjectgelatinase A
dc.subjectgelatinase B
dc.subjectgrowth factor
dc.subjectimmunoglobulin enhancer binding protein
dc.subjectinterleukin 10
dc.subjectinterleukin 12
dc.subjectinterleukin 6
dc.subjectmatrix metalloproteinase
dc.subjectmatrix metalloproteinase 14
dc.subjectmyeloperoxidase
dc.subjectneutrophil collagenase
dc.subjectreactive oxygen metabolite
dc.subjectvasculotropin A
dc.subjectmatrix metalloproteinase
dc.subjectadaptation
dc.subjectbioavailability
dc.subjectcarcinogenesis
dc.subjectdisease course
dc.subjectextracellular matrix
dc.subjectfeedback system
dc.subjectgenetic polymorphism
dc.subjecthuman
dc.subjectimmunity
dc.subjectinflammation
dc.subjectkinetics
dc.subjectmacrophage
dc.subjectosteolysis
dc.subjectperiodontal disease
dc.subjectreceptor down regulation
dc.subjectReview
dc.subjectsignal transduction
dc.subjectwound healing
dc.subjectbiological model
dc.subjectenzyme activation
dc.subjectenzymology
dc.subjectinflammation
dc.subjectmetabolism
dc.subjectperiodontal disease
dc.subjectEnzyme Activation
dc.subjectHumans
dc.subjectInflammation
dc.subjectMatrix Metalloproteinases
dc.subjectModels, Biological
dc.subjectPeriodontal Diseases
dc.subjectSignal Transduction
dc.titleMatrix metalloproteinases as regulators of periodontal inflammation
dc.typeReview


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