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Neuroprotective effects of curcumin through autophagy modulation

dc.contributor.authorForouzanfar F.
dc.contributor.authorRead M.I.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:17:57Z
dc.date.available2020-09-02T22:17:57Z
dc.date.issued2020
dc.identifier10.1002/iub.2209
dc.identifier.citation72, 4, 652-664
dc.identifier.issn15216543
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4517
dc.descriptionAutophagy is a highly conserved cellular degradation process involving lysosomal degradation for the turnover of proteins, protein complexes, and organelles. Defects in autophagy produces impaired intercellular communication and have subsequently been shown to be associated with pathological conditions, including neurodegenerative diseases. Curcumin is a polyphenol found in the rhizome of Curcuma longa, which has been shown to exert health benefits, such as antimicrobial, antioxidant, anti-inflammatory, and anticancer effects. There is increasing evidence in the literature revealing that autophagy modulation may provide neuroprotective effects. In light of this, our current review aims to address recent advances in the neuroprotective role of curcumin-induced autophagy modulation, specifically with a particular focus on its effects in Alexander disease, Alzheimer's disease, ischemia stroke, traumatic brain injury, and Parkinson's disease. © 2019 International Union of Biochemistry and Molecular Biology
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.subjectantioxidant
dc.subjectautophagy
dc.subjectcurcumin
dc.subjectmolecular mechanisms
dc.subjectbiological marker
dc.subjectcurcumin
dc.subjectAlexander disease
dc.subjectAlzheimer disease
dc.subjectautophagy (cellular)
dc.subjectbrain cancer
dc.subjectbrain ischemia
dc.subjectcerebral ischemia reperfusion injury
dc.subjectdiabetes mellitus
dc.subjectdrug bioavailability
dc.subjectdrug mechanism
dc.subjecthuman
dc.subjectneuroprotection
dc.subjectnonhuman
dc.subjectParkinson disease
dc.subjectperipheral nerve injury
dc.subjectReview
dc.subjectspinal cord injury
dc.subjecttraumatic brain injury
dc.titleNeuroprotective effects of curcumin through autophagy modulation
dc.typeReview


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