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Modulation of heat shock proteins by statins

dc.contributor.authorForouzanfar F.
dc.contributor.authorButler A.E.
dc.contributor.authorBanach M.
dc.contributor.authorBarreto G.E.
dc.contributor.authorSahbekar A.
dc.date.accessioned2020-09-02T22:17:57Z
dc.date.available2020-09-02T22:17:57Z
dc.date.issued2018
dc.identifier10.1016/j.phrs.2018.06.020
dc.identifier.citation134, , 134-144
dc.identifier.issn10436618
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4516
dc.descriptionHeat shock proteins (HSP or stress proteins) are intracellular molecules that participate in physiological cell metabolism and growth, although they are known to be involved in many stress conditions. Statins inhibit the action of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA), which is important in the synthesis of cholesterol and essential isoprenoid intermediates, thereby lowering circulating low-density lipoprotein cholesterol (LDL), a major risk factor for cardiovascular disease (CVD). This review provides new insights into the mechanisms of action of statins in the regulation of HSPs. A better understanding of this involvement can help in development of new and more effective treatment strategies for CVD. © 2018 Elsevier Ltd
dc.language.isoen
dc.publisherAcademic Press
dc.subjectAtherogenesis
dc.subjectHeat shock proteins
dc.subjectHMG-CoA
dc.subjectStatin
dc.subjectalpha crystallin
dc.subjectatorvastatin
dc.subjectbeta crystallin
dc.subjectC reactive protein
dc.subjectcalnexin
dc.subjectcalreticulin
dc.subjectcerivastatin
dc.subjectchaperonin 60
dc.subjectcholesterol
dc.subjectfluindostatin
dc.subjectglucose regulated protein 78
dc.subjectglycoprotein gp 96
dc.subjectheat shock cognate protein 70
dc.subjectheat shock protein
dc.subjectheat shock protein 110
dc.subjectheat shock protein 27
dc.subjectheat shock protein 40
dc.subjectheat shock protein 47
dc.subjectheat shock protein 70
dc.subjectheat shock protein 90
dc.subjecthigh density lipoprotein cholesterol
dc.subjecthydroxymethylglutaryl coenzyme A reductase
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectisoprenoid
dc.subjectlow density lipoprotein cholesterol
dc.subjectmevinolin
dc.subjectrosuvastatin
dc.subjectsimvastatin
dc.subjecttriacylglycerol
dc.subjectunindexed drug
dc.subjectheat shock protein
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectlipid
dc.subjectangiogenesis
dc.subjectatherosclerosis
dc.subjectcardiovascular disease
dc.subjectcholesterol blood level
dc.subjectcholesterol synthesis
dc.subjectdrug mechanism
dc.subjecthuman
dc.subjecthypercholesterolemia
dc.subjectmodulation
dc.subjectpleiotropy
dc.subjectpriority journal
dc.subjectprotein function
dc.subjectprotein localization
dc.subjectReview
dc.subjectrisk factor
dc.subjecttriacylglycerol blood level
dc.subjectanimal
dc.subjectblood
dc.subjectcardiovascular disease
dc.subjectcomplication
dc.subjectdrug effect
dc.subjectdyslipidemia
dc.subjectmetabolism
dc.subjectsignal transduction
dc.subjectAnimals
dc.subjectCardiovascular Diseases
dc.subjectDyslipidemias
dc.subjectHeat-Shock Proteins
dc.subjectHumans
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors
dc.subjectLipids
dc.subjectSignal Transduction
dc.titleModulation of heat shock proteins by statins
dc.typeReview


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