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Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

dc.contributor.authorForouzanfar F.
dc.contributor.authorBarreto G.
dc.contributor.authorMajeed M.
dc.contributor.authorSahebkar A.
dc.date.accessioned2020-09-02T22:17:57Z
dc.date.available2020-09-02T22:17:57Z
dc.date.issued2019
dc.identifier10.1002/biof.1522
dc.identifier.citation45, 5, 631-640
dc.identifier.issn09516433
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4514
dc.descriptionCancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress-inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti-inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs. © 2019 International Union of Biochemistry and Molecular Biology
dc.language.isoen
dc.publisherBlackwell Publishing Inc.
dc.subjectcancer
dc.subjectcurcumin
dc.subjectheat shock protein
dc.subjectherbal medicine
dc.subjectchaperonin 60
dc.subjectcurcumin
dc.subjectheat shock protein
dc.subjectheat shock protein 27
dc.subjectheat shock protein 40
dc.subjectantineoplastic agent
dc.subjectchaperone
dc.subjectchaperonin 60
dc.subjectcurcumin
dc.subjectDNAJB1 protein, human
dc.subjectheat shock protein
dc.subjectheat shock protein 40
dc.subjectheat shock protein 70
dc.subjectheat shock protein 90
dc.subjectHSPB1 protein, human
dc.subjectHSPD1 protein, human
dc.subjectmitochondrial protein
dc.subjecttumor protein
dc.subjectherbal medicine
dc.subjecthuman
dc.subjectmalignant neoplasm
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectReview
dc.subjectdrug effect
dc.subjectgene expression regulation
dc.subjectgenetics
dc.subjectlymph node metastasis
dc.subjectmetabolism
dc.subjectneoplasm
dc.subjectneovascularization (pathology)
dc.subjectpathology
dc.subjectsignal transduction
dc.subjecttumor microenvironment
dc.subjectAntineoplastic Agents, Phytogenic
dc.subjectChaperonin 60
dc.subjectCurcumin
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectHeat-Shock Proteins
dc.subjectHSP40 Heat-Shock Proteins
dc.subjectHSP70 Heat-Shock Proteins
dc.subjectHSP90 Heat-Shock Proteins
dc.subjectHumans
dc.subjectLymphatic Metastasis
dc.subjectMitochondrial Proteins
dc.subjectMolecular Chaperones
dc.subjectNeoplasm Proteins
dc.subjectNeoplasms
dc.subjectNeovascularization, Pathologic
dc.subjectSignal Transduction
dc.subjectTumor Microenvironment
dc.titleModulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach
dc.typeReview


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