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Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity
dc.contributor.author | Fonseca D. | |
dc.contributor.author | Leal-Pinto S.M. | |
dc.contributor.author | Roa-Cordero M.V. | |
dc.contributor.author | Vargas J.D. | |
dc.contributor.author | Moreno-Moreno E.M. | |
dc.contributor.author | Macías M.A. | |
dc.contributor.author | Suescun L. | |
dc.contributor.author | Muñoz-Castro Á. | |
dc.contributor.author | Hurtado J.J. | |
dc.date.accessioned | 2020-09-02T22:17:55Z | |
dc.date.available | 2020-09-02T22:17:55Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.3390/ijms20133237 | |
dc.identifier.citation | 20, 13, - | |
dc.identifier.issn | 16616596 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12728/4498 | |
dc.description | Seven cobalt(II) complexes of pyrazole derivatives and dinitrobenzoate ligands were synthesized and characterized. The single-crystal X-ray diffraction structure was determined for one of the ligands and one of the complexes. The analysis and spectral data showed that all the cobalt complexes had octahedral geometries, which was supported by DFT calculations. The complexes and their free ligands were evaluated against fungal strains of Candida albicans and emerging non-albicans species and epimastigotes of Trypanosoma cruzi. We obtained antifungal activity with a minimum inhibitory concentration (MIC) ranging from 31.3 to 250 µg mL−1 . The complexes were more active against C. krusei, showing MIC values between 31.25 and 62.5 µg mL−1 . In addition, some ligands (L1–L6) and complexes (5 and Co(OAc)2 · 4H2 O) significantly reduced the yeast to hypha transition of C. albicans at 500 µg mL−1 (inhibition ranging from 30 to 54%). Finally, the complexes and ligands did not present trypanocidal activity and were not toxic to Vero cells. Our results suggest that complexes of cobalt(II) with ligands derived from pyrazoles and dinitrobenzoate may be an attractive alternative for the treatment of diseases caused by fungi, especially because they target one of the most important virulence factors of C. albicans. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | |
dc.language.iso | en | |
dc.publisher | MDPI AG | |
dc.subject | Antifungal activity | |
dc.subject | Cobalt(II) complexes | |
dc.subject | Crystal structure | |
dc.subject | Cytotoxicity | |
dc.subject | Dimorphic switch | |
dc.subject | Pyrazole and dinitrobenzoate ligands | |
dc.subject | Trypanosoma cruzi | |
dc.subject | 2,6 bis(3,5 dimethyl 1 pyrazolyl)pyridine | |
dc.subject | 2,6 bis(3,5 dimethyl 4 nitro1pyrazolyl)pyridine | |
dc.subject | 3,5 bis(3,5 dimethyl 4 nitropyrazol 1 ylmethyl)toluene | |
dc.subject | benznidazole | |
dc.subject | bis(3,5 dimethyl 1 pyrazolyl)methane | |
dc.subject | bis(3,5 dimethyl 4 nitro 1 pyrazolyl)methane | |
dc.subject | bis(dinitrobenzoate o,o’) | |
dc.subject | cobalt complex | |
dc.subject | dinitrobenzoate | |
dc.subject | dinitrobenzoate[2,6 bis(3,5 dimethyl 4 nitro pyrazol 1 ylmethyl)pyridine] | |
dc.subject | dinitrobenzoate[2,6 bis(3,5 dimethylpyrazol 1 ylmethyl)pyridine] | |
dc.subject | dinitrobenzoate[3,5 bis(3,5 dimethyl 4 nitro pyrazol 1 ylmethyl)toluene] | |
dc.subject | dinitrobenzoate[3,5 bis(3,5 dimethylpyrazol 1 ylmethyl)toluene] | |
dc.subject | dinitrobenzoate[bis(3,5 dimethyl 4 nitro pyrazol 1yl)methane] | |
dc.subject | dinitrobenzoate[bis(3,5 dimethylpyrazol 1 yl)methane] | |
dc.subject | itraconazole | |
dc.subject | nitrobenzoic acid derivative | |
dc.subject | pyrazole | |
dc.subject | unclassified drug | |
dc.subject | antiinfective agent | |
dc.subject | cobalt | |
dc.subject | coordination compound | |
dc.subject | ligand | |
dc.subject | nitrobenzene derivative | |
dc.subject | pyrazole derivative | |
dc.subject | animal cell | |
dc.subject | antibiotic sensitivity | |
dc.subject | antifungal activity | |
dc.subject | Article | |
dc.subject | bioassay | |
dc.subject | biological activity | |
dc.subject | broth dilution | |
dc.subject | Candida albicans | |
dc.subject | Candida tropicalis | |
dc.subject | carbon nuclear magnetic resonance | |
dc.subject | controlled study | |
dc.subject | crystal structure | |
dc.subject | crystallization | |
dc.subject | cytotoxicity | |
dc.subject | drug synthesis | |
dc.subject | electrospray | |
dc.subject | elemental analysis | |
dc.subject | Fourier transform infrared spectroscopy | |
dc.subject | fungus hyphae | |
dc.subject | gas chromatography | |
dc.subject | germ tube inhibition assay | |
dc.subject | growth inhibition | |
dc.subject | IC50 | |
dc.subject | infrared spectroscopy | |
dc.subject | mass spectrometry | |
dc.subject | melting point | |
dc.subject | minimum inhibitory concentration | |
dc.subject | MTT assay | |
dc.subject | nonhuman | |
dc.subject | Pichia kudriavzevii | |
dc.subject | proton nuclear magnetic resonance | |
dc.subject | Raman spectrometry | |
dc.subject | Trypanosoma cruzi | |
dc.subject | ultraviolet visible spectrophotometry | |
dc.subject | Vero cell line | |
dc.subject | X ray diffraction | |
dc.subject | animal | |
dc.subject | Candida albicans | |
dc.subject | cell survival | |
dc.subject | chemical structure | |
dc.subject | chemistry | |
dc.subject | Chlorocebus aethiops | |
dc.subject | drug effect | |
dc.subject | microbial sensitivity test | |
dc.subject | structure activity relation | |
dc.subject | synthesis | |
dc.subject | X ray crystallography | |
dc.subject | Animals | |
dc.subject | Anti-Bacterial Agents | |
dc.subject | Candida albicans | |
dc.subject | Cell Survival | |
dc.subject | Chlorocebus aethiops | |
dc.subject | Cobalt | |
dc.subject | Coordination Complexes | |
dc.subject | Crystallography, X-Ray | |
dc.subject | Dinitrobenzenes | |
dc.subject | Ligands | |
dc.subject | Microbial Sensitivity Tests | |
dc.subject | Molecular Structure | |
dc.subject | Pyrazoles | |
dc.subject | Structure-Activity Relationship | |
dc.subject | Vero Cells | |
dc.title | Inhibition of C. albicans dimorphic switch by cobalt(II) complexes with ligands derived from pyrazoles and dinitrobenzoate: Synthesis, characterization and biological activity | |
dc.type | Article |