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Experimental models for aging and their potential for novel drug discovery

dc.contributor.authorFolch J.
dc.contributor.authorBusquets O.
dc.contributor.authorEttcheto M.
dc.contributor.authorSánchez-López E.
dc.contributor.authorPallàs M.
dc.contributor.authorBeas-Zarate C.
dc.contributor.authorMarin M.
dc.contributor.authorCasadesus G.
dc.contributor.authorOlloquequi J.
dc.contributor.authorAuladell C.
dc.contributor.authorCamins A.
dc.date.accessioned2020-09-02T22:17:53Z
dc.date.available2020-09-02T22:17:53Z
dc.date.issued2018
dc.identifier10.2174/1570159X15666170707155345
dc.identifier.citation16, 10, 1466-1483
dc.identifier.issn1570159X
dc.identifier.urihttps://hdl.handle.net/20.500.12728/4489
dc.descriptionBackground: An interesting area of scientific research is the development of potential antiaging drugs. In order to pursue this goal, it is necessary to gather the specific knowledge about the adequate preclinical models that are available to evaluate the beneficial effects of new potential drugs. This review is focused on invertebrate and vertebrate preclinical models used to evaluate the efficacy of antiaging compounds, with the objective to extend life span and health span. Methods: Research and online content related to aging, antiaging drugs, experimental aging models is reviewed. Moreover, in this review, the main experimental preclinical models of organisms that have contributed to the research in the pharmacology of lifespan extension and the understanding of the aging process are discussed. Results: Dietary restriction (DR) constitutes a common experimental process to extend life span in all organisms. Besides, classical antiaging drugs such as resveratrol, rapamycin and metformin denominated as DR mimetics are also discussed. Likewise, the main therapeutic targets of these drugs include sirtuins, IGF-1, and mTOR, all of them being modulated by DR. Conclusion: Advances in molecular biology have uncovered the potential molecular pathways involved in the aging process. Due to their characteristics, invertebrate models are mainly used for drug screening. The National Institute on Aging (NIA) developed the Interventions Testing Program (ITP). At the preclinical level, the ITP uses Heterogeneous mouse model (HET) which is probably the most suitable rodent model to study potential drugs against aging prevention. The accelerated-senescence mouse P8 is also a mammalian rodent model for aging research. However, when evaluating the effect of drugs on a preclinical level, the evaluation must be done in non-human primates since it is the mammalian specie closest to humans. Research is needed to investigate the impact of new potential drugs for the increase of human quality of life. © 2018 Bentham Science Publishers.
dc.language.isoen
dc.publisherBentham Science Publishers B.V.
dc.subjectAging
dc.subjectHeterogeneous mice model
dc.subjectIGF-1
dc.subjectmTOR
dc.subjectResveratrol
dc.subjectSAMP8
dc.subjectSirtuins
dc.subjectantiinflammatory agent
dc.subjectmammalian target of rapamycin
dc.subjectmetformin
dc.subjectneurotoxin
dc.subjectphosphatidylinositide
dc.subjectprotein kinase B
dc.subjectprotein p53
dc.subjectrapamycin
dc.subjectreactive oxygen metabolite
dc.subjectresveratrol
dc.subjectsirtuin
dc.subjectsomatomedin C receptor
dc.subjecttranscription factor
dc.subjectaging
dc.subjectAlzheimer disease
dc.subjectCaenorhabditis elegans
dc.subjectcaloric restriction
dc.subjectclinical trial (topic)
dc.subjectcoronary artery disease
dc.subjectdegenerative disease
dc.subjectdiabetes mellitus
dc.subjectdiet supplementation
dc.subjectDNA repair
dc.subjectDrosophila
dc.subjectdrug efficacy
dc.subjectdrug synthesis
dc.subjectenzyme activity
dc.subjectexperimental model
dc.subjectgene mutation
dc.subjecthistopathology
dc.subjecthuman
dc.subjectinsulin signaling
dc.subjectkillifish
dc.subjectlife expectancy
dc.subjectlife extension
dc.subjectmTOR signaling
dc.subjectnerve degeneration
dc.subjectneurologic disease
dc.subjectneuroprotection
dc.subjectnon insulin dependent diabetes mellitus
dc.subjectnonhuman
dc.subjectNothobranchius furzeri
dc.subjectoxidative stress
dc.subjectphenotype
dc.subjectquality of life
dc.subjectReview
dc.subjectSaccharomyces cerevisiae
dc.subjectaging
dc.subjectanimal
dc.subjectanimal model
dc.subjectdrug development
dc.subjectdrug effect
dc.subjectphysiology
dc.subjectprocedures
dc.subjectAging
dc.subjectAnimals
dc.subjectDrug Discovery
dc.subjectModels, Animal
dc.titleExperimental models for aging and their potential for novel drug discovery
dc.typeReview


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